Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …

Brain computation is metabolically expensive and requires the supply of significant amounts
of energy. Mitochondria are highly specialized organelles whose main function is to …

Calcium (Ca 2+) is a key regulator in diverse intracellular signaling pathways and has long
been implicated in metabolic control and mitochondrial function. Mitochondria can actively …

Ion homeostasis distortion through exogenous overload or underload of intracellular ion
species has become an arresting therapeutic approach against malignant tumor …

Calcium is a major regulator of cellular metabolism. Calcium controls mitochondrial
respiration, and calcium signaling is used to meet cellular energetic demands through …

L-type voltage-gated calcium channels are involved in multiple physiological functions.
Currently available antagonists do not discriminate between L-type channel isoforms …

The mitochondrial calcium uniporter (MCU) is the main route of calcium (Ca2+) entry into
neuronal mitochondria. This channel has been linked to mitochondrial Ca2+ overload and …

Background Bioenergetic maladaptations and axonopathy are often found in the early
stages of neurodegeneration. Nicotinamide adenine dinucleotide (NAD), an essential …

Parkinson's disease (PD) is a neurodegenerative disease caused by multifactorial
pathogenic mechanisms. Familial PD is linked with genetic mutations in genes whose …

Brain tissue metabolism is distributed across several cell types and subcellular
compartments, which activate at different times and with different temporal patterns. The …