Neurodegenerative diseases are characterized by neuroinflammation, neuronal depletion
and oxidative stress. They coincide with subtle chronic or flaring inflammation, sometimes …

Molecular diagnostics provide a powerful method to detect and diagnose various
neurological diseases such as Alzheimer's and Parkinson's disease. The confirmation of …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects
motor neurons. Mutations in the SPTLC1 subunit of serine palmitoyltransferase (SPT), which …

The central nervous system (CNS) is vulnerable to pathologic processes that lead to the
development of neurodegenerative disorders like Alzheimer's, Parkinson's and Huntington's …

Amyotrophic lateral sclerosis (ALS) is the commonest form of motor neuron disease and is a
fatal, degenerative, multisystem disorder affecting upper and/or lower motor neurons in the …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease for which
there is currently no cure. Progress in the characterization of other neurodegenerative …

Cell transplantation is an attractive treatment strategy for a variety of brain disorders, as it
promises to replenish lost functions and rejuvenate the brain. In particular, transplantation of …

Background Amyotrophic lateral sclerosis (ALS) is a debilitating disease with few treatment
options. Progress towards new therapies requires validated disease biomarkers, but there is …

DNA methylation primarily occurs within human cells as a 5-methylcytosine (5mC)
modification of the cytosine bases in CpG dinucleotides. 5mC has proven to be an important …

Since NLRP3 inflammasome plays a pivotal role in several neurodegenerative disorders,
we hypothesized that levels of inflammasome components could help in diagnosis or …