Hepatocyte apoptosis plays an essential role in the progression of nonalcoholic
steatohepatitis (NASH). However, the molecular mechanisms underlying hepatocyte …

Human gene therapy has advanced from twentieth-century conception to twenty-first-century
reality. The recombinant Adeno-Associated Virus (rAAV) is a major gene therapy vector …

The capsid structures of most Adeno-associated virus (AAV) serotypes, already assigned to
an antigenic clade, have been previously determined. This study reports the remaining …

A number of preclinical studies have shown the adeno-associated virus (AAV) to be an
efficient vehicle for gene therapy. Clinical studies successfully demonstrated its potential for …

Adeno-associated virus serotype 9 (AAV9) vectors show promise for gene therapy of a
variety of diseases due to their ability to transduce multiple tissues, including heart, skeletal …

Adeno-associated viruses (AAVs) are small nonenveloped single-stranded DNA (ssDNA)
viruses that are currently being developed as gene therapy biologics. After cell entry, AAVs …

The recombinant adeno-associated virus (rAAV) gene delivery system is entering a crucial
and exciting phase with the promise of more than 20 years of intense research now realized …

The three-dimensional structure of adeno-associated virus (AAV) serotype 6 (AAV6) was
determined using cryo-electron microscopy and image reconstruction and using X-ray …

Viruses can be engineered to efficiently deliver exogenous genes, but their natural gene
delivery properties often fail to meet human therapeutic needs. Therefore, engineering viral …

Interactions between viruses and the host antibody immune response are critical in the
development and control of disease, and antibodies are also known to interfere with the …