Over the past two decades, the molecular machinery that underlies autophagic responses
has been characterized with ever increasing precision in multiple model organisms …

Abnormalities of the endosomal–lysosomal network (ELN) are a signature feature of
Alzheimer's disease (AD). These include the earliest known cytopathology that is specific to …

Type I programmed cell death (PCD) or apoptosis is critical for cellular self-destruction for a
variety of processes such as development or the prevention of oncogenic transformation …

The increase in human life expectancy has become a challenge to reduce the deleterious
consequences of aging. Nowadays, an increasing number of the population suffer from age …

Mitochondria are highly dynamic organelles of crucial importance to the proper functioning
of neuronal, cardiac and other cell types dependent upon aerobic efficiency. Mitochondrial …

Despite the progress of the past two decades, the cause of Alzheimer's disease (AD) and
effective treatments against it remain elusive. The hypothesis that amyloid-β (Aβ) peptides …

Impaired brain energy metabolism and oxidative stress are implicated in cognitive decline
and the pathologic accumulations of amyloid β-peptide (Aβ) and hyperphosphorylated tau in …

Age-related macular degeneration (AMD) is a complex eye disease with many pathogenesis
factors, including defective cellular waste management in retinal pigment epithelium (RPE) …

The study of rare, inherited mutations underlying familial forms of Parkinson's disease has
provided insight into the molecular mechanisms of disease pathogenesis. Mutations in these …

Autophagy is a catabolic process involving lysosomal turnover of proteins and organelles for
maintenance of cellular homeostasis and mitigation of metabolic stress. Autophagy defects …