Novel findings in neutrophil biology and their impact on cardiovascular disease

A Bonaventura, F Montecucco, F Dallegri… - Cardiovascular …, 2019 - academic.oup.com
Neutrophils are the most abundant circulating leucocytes in healthy humans. These cells are
central players during acute inflammatory responses, although a growing body of evidence …

Current state and future perspective of cardiovascular medicines derived from natural products

C Zhao, S Li, J Zhang, Y Huang, L Zhang… - Pharmacology & …, 2020 - Elsevier
The contribution of natural products (NPs) to cardiovascular medicine has been extensively
documented, and many have been used for centuries. Cardiovascular disease (CVD) is the …

[HTML][HTML] TFEB-NF-κB inflammatory signaling axis: a novel therapeutic pathway of Dihydrotanshinone I in doxorubicin-induced cardiotoxicity

X Wang, Q Wang, W Li, Q Zhang, Y Jiang… - Journal of Experimental …, 2020 - Springer
Background Doxorubicin is effective in a variety of solid and hematological malignancies.
Unfortunately, clinical application of doxorubicin is limited due to a cumulative dose …

[HTML][HTML] Guggulsterone mediated JAK/STAT and PPAR-gamma modulation prevents neurobehavioral and neurochemical abnormalities in propionic acid-induced …

R Khera, S Mehan, S Bhalla, S Kumar, A Alshammari… - Molecules, 2022 - mdpi.com
Autism spectrum disorder is a neurodevelopmental disorder marked by repetitive behaviour,
challenges in verbal and non-verbal communication, poor socio-emotional health, and …

Research Progress of Chinese Medicine in the Treatment of Myocardial Ischemia–Reperfusion Injury

L Dong, Z Shen, H Chi, Y Wang, Z Shi… - The American Journal …, 2023 - World Scientific
Vascular recanalization is the essential procedure in which severe coronary artery stenosis
is diagnosed. However, the blood flow recovery associated with this procedure may cause …

[HTML][HTML] Cardiomyocyte death in sepsis: mechanisms and regulation

G Zhang, D Dong, X Wan… - Molecular Medicine …, 2022 - spandidos-publications.com
Sepsis‑induced cardiac dysfunction is one of the most common types of organ dysfunction in
sepsis; its pathogenesis is highly complex and not yet fully understood. Cardiomyocytes …

[HTML][HTML] Pharmacological basis of tanshinone and new insights into tanshinone as a multitarget natural product for multifaceted diseases

Z Li, J Zou, D Cao, X Ma - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Drug development has long included the systematic exploration of various resources.
Among these, natural products are one of the most important resources from which novel …

PI3K/AKT/mTOR signalling inhibitor chrysophanol ameliorates neurobehavioural and neurochemical defects in propionic acid-induced experimental model of autism …

A Sharma, S Bhalla, S Mehan - Metabolic brain disease, 2022 - Springer
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder marked by
social and communication deficits as well as repetitive behaviour. Several studies have …

[HTML][HTML] Tanshinone I Inhibits Oxidative Stress–Induced Cardiomyocyte Injury by Modulating Nrf2 Signaling

YT Wu, LP Xie, Y Hua, HL Xu, GH Chen… - Frontiers in …, 2021 - frontiersin.org
Cardiovascular disease, a disease caused by many pathogenic factors, is one of the most
common causes of death worldwide, and oxidative stress plays a major role in its …

TanshinoneⅡA inhibits excessive autophagy and protects myocardium against ischemia/reperfusion injury via 14-3-3η/Akt/Beclin1 pathway

L Wen, X Cheng, Q Fan, Z Chen, Z Luo, T Xu… - European Journal of …, 2023 - Elsevier
Excessive autophagy induced by reperfusion is one of the causes of severe myocardial
injury. Tanshinone IIA (TSN) protects the myocardium against ischemia/reperfusion (I/R) …