Intracellular signalling pathways have provided excellent resource for drug development
particularly in the development of cancer therapeutics. A wide variety of malignancies …

All patients with metastatic lung, colorectal, pancreatic or head and neck cancers who
initially benefit from epidermal growth factor receptor (EGFR)-targeted therapies eventually …

Importance of the field: Nuclear factor kappa B (NF-κB) is activated by a variety of cancer-
promoting agents. The reciprocal activation between NF-κB and inflammatory cytokines …

Importance Patients with familial adenomatous polyposis (FAP) are at markedly increased
risk for duodenal polyps and cancer. Surgical and endoscopic management of duodenal …

Introduction 3. NF-kappaB activation pathways 3.1. Protein components in the NF-kappaB
family 3.2. The pathways leading to NF-kappaB activation 4. NF-kappaB's cellular functions …

The ubiquitin–proteasome system is a major pathway for protein degradation, so that
proteasome is now considered as an important target for drug discovery. Bortezomib, the …

Importance Patients with familial adenomatous polyposis (FAP) are at markedly increased
risk for colorectal polyps and cancer. A combination of sulindac and erlotinib led to a 71 …

Bortezomib (BTZ) is the first clinically approved proteasome inhibitor for treating multiple
human malignancies. However, the poor water-solubility and low stability of BTZ and the …

Purpose Pneumonitis is a significant toxicity of EGFR tyrosine kinase inhibitors (EGFR-TKI)
in non-small-cell lung cancer (NSCLC) patients. We studied the incidence of pneumonitis in …

Abstract KRAS (Kirsten Rat Sarcoma) is the most common oncogenic mutation detected in
patients with non-small cell lung cancer (NSCLC). However, the role of KRAS as either a …