Human leukocyte antigen class I (HLA-I) molecules are encoded by major histocompatibility
complex (MHC) class I loci in humans. The binding and interaction between HLA-I …

In this paper, current prediction methods and algorithms for both T‐and B cell epitopes are
reviewed, and a comprehensive summary of epitope prediction software and databases …

Background Binding of peptides to Major Histocompatibility Complex (MHC) molecules is
the single most selective step in the recognition of pathogens by the cellular immune system …

Background Initiation and regulation of immune responses in humans involves recognition
of peptides presented by human leukocyte antigen class II (HLA-II) molecules. These …

Molecular docking programs play an important role in drug development and many well‐
established methods exist. However, there are two situations for which the performance of …

Biotherapeutics, and antimicrobial proteins in particular, are of increasing interest for human
medicine. An important challenge in the development of such therapeutics is their potential …

Peptide-protein interactions are ubiquitous in the cell and form an important part of the
interactome. Computational docking methods can complement experimental …

Molecular chaperones are essential elements of the protein quality control machinery that
governs translocation and folding of nascent polypeptides, refolding and degradation of …

Understanding the mechanisms involved in the activation of an immune response is
essential to many fields in human health, including vaccine development and personalized …

The class I proteins of the major histocompatibility complex (MHC-I) display epitopic
peptides derived from endogenous proteins on the cell surface for immune surveillance …