Since the discovery of the chromosome 9 open reading frame 72 (C9orf72) repeat
expansion mutation in 2011 as the most common genetic abnormality in amyotrophic lateral …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that has no
effective treatment. The lack of any specific biomarker that can help in the diagnosis or …

Now that genetic testing can identify persons at risk for developing amyotrophic lateral
sclerosis (ALS) many decades before symptoms begin, there is a critical need for …

Introduction Amyotrophic lateral sclerosis (ALS) is an invariably lethal progressive disease,
causing degeneration of neurons and muscle. No current treatment halts or reverses …

By employing chip-based capillary zone electrophoresis coupled to high-resolution mass
spectrometry, we profiled the plasma metabolome of 134 patients diagnosed with sporadic …

This review details our current understanding of thrombin signaling in neurodegeneration,
with a focus on amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease) as well as future …

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease. Since there
are no pathognomonic tests for ALS prognoses; clinical diagnoses of the disease take time …

Background Amyotrophic lateral sclerosis (ALS) is a progressive and fatal motor neuron
disease. Due to the limited knowledge about potential biomarkers that help in early …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in adults involving
non-demyelinating motor disorders. About 90% of ALS cases are sporadic, while 10–12% of …

A pathogenic GGGCCC hexanucleotide expansion in the first intron/promoter region of the
C9orf72 gene is the most common mutation associated with amyotrophic lateral sclerosis …