Due to improved phenotyping and genetic characterization, the field of 'incurable'and
'blinding'inherited retinal diseases (IRDs) has moved substantially forward. Decades of …

Colour vision deficiency is one of the commonest disorders of vision and can be divided into
congenital and acquired forms. Congenital colour vision deficiency affects as many as 8% of …

Acquired color vision deficiency occurs as the result of ocular, neurologic, or systemic
disease. A wide array of conditions may affect color vision, ranging from diseases of the …

Ciliary neurotrophic factor (CNTF) is one of the most studied neurotrophic factors for
neuroprotection of the retina. A large body of evidence demonstrates that CNTF promotes …

In 2001, the first large animal was successfully treated with a gene therapy that restored its
vision. Lancelot, the Briard dog that was treated, suffered from a human childhood blindness …

It is important to understand the balance between cortical plasticity and stability in various
systems and across spatial scales in the adult brain. Here we review studies of adult …

The cone dysfunction syndromes are a heterogeneous group of inherited, predominantly
stationary retinal disorders characterised by reduced central vision and varying degrees of …

Congenital absence of cone photoreceptor function is associated with strongly impaired
daylight vision and loss of color discrimination in human achromatopsia. Here, we introduce …

Retinal cone photoreceptors mediate fine visual acuity, daylight vision, and color vision.
Congenital hereditary conditions in which there is a lack of cone function in humans cause …

Inherited retinal degenerations are a common cause of untreatable blindness worldwide,
with retinitis pigmentosa and cone dystrophy affecting approximately 1 in 3500 and 1 in …