The state of complement in COVID-19
Hyperactivation of the complement and coagulation systems is recognized as part of the
clinical syndrome of COVID-19. Here we review systemic complement activation and local …
clinical syndrome of COVID-19. Here we review systemic complement activation and local …
Immunity, endothelial injury and complement-induced coagulopathy in COVID-19
In December 2019, a novel coronavirus was isolated from the respiratory epithelium of
patients with unexplained pneumonia in Wuhan, China. This pathogen, named severe acute …
patients with unexplained pneumonia in Wuhan, China. This pathogen, named severe acute …
Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies
Antibody-based drugs and vaccines against severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) are being expedited through preclinical and clinical development. Data …
2 (SARS-CoV-2) are being expedited through preclinical and clinical development. Data …
The SARS-CoV-2 nucleocapsid protein: its role in the viral life cycle, structure and functions, and use as a potential target in the development of vaccines and …
W Wu, Y Cheng, H Zhou, C Sun, S Zhang - Virology journal, 2023 - Springer
Abstract Coronavirus disease 2019 (COVID-19) continues to take a heavy toll on personal
health, healthcare systems, and economies around the globe. Scientists are expending …
health, healthcare systems, and economies around the globe. Scientists are expending …
The emerging threat of (micro) thrombosis in COVID-19 and its therapeutic implications
JD McFadyen, H Stevens, K Peter - Circulation research, 2020 - Am Heart Assoc
The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing global pandemic has presented a health emergency of unprecedented …
and the ensuing global pandemic has presented a health emergency of unprecedented …
COVID-19 and multiorgan failure: A narrative review on potential mechanisms
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) in
December 2019 form Wuhan, China leads to coronavirus disease 2019 (COVID-19) …
December 2019 form Wuhan, China leads to coronavirus disease 2019 (COVID-19) …
Association of COVID-19 inflammation with activation of the C5a–C5aR1 axis
J Carvelli, O Demaria, F Vély, L Batista… - Nature, 2020 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is a disease caused by infection with severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in a pandemic …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in a pandemic …
Complement and tissue factor–enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis
P Skendros, A Mitsios… - The Journal of …, 2020 - Am Soc Clin Investig
Emerging data indicate that complement and neutrophils contribute to the maladaptive
immune response that fuels hyperinflammation and thrombotic microangiopathy, thereby …
immune response that fuels hyperinflammation and thrombotic microangiopathy, thereby …
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
JC Holter, SE Pischke, E de Boer… - Proceedings of the …, 2020 - National Acad Sciences
Respiratory failure in the acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
pandemic is hypothesized to be driven by an overreacting innate immune response, where …
pandemic is hypothesized to be driven by an overreacting innate immune response, where …
Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition
J Yu, X Yuan, H Chen, S Chaturvedi… - Blood, The Journal …, 2020 - ashpublications.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious
respiratory virus that can lead to venous/arterial thrombosis, stroke, renal failure, myocardial …
respiratory virus that can lead to venous/arterial thrombosis, stroke, renal failure, myocardial …