Amyloid-β: an antioxidant that becomes a pro-oxidant and critically contributes to Alzheimer's disease

A Kontush - Free Radical Biology and Medicine, 2001 - Elsevier
Elevated production of amyloid-β (Aβ) as a preventive antioxidant for brain lipoproteins
under the action of increased oxidative stress in aging is postulated to represent a major …

Elevation of oxidative free radicals in Alzheimer's disease models can be attenuated by Ginkgo biloba extract EGb 761

JV Smith, Y Luo - Journal of Alzheimer's Disease, 2003 - content.iospress.com
The role of amyloid β-peptide (Aβ) in the free-radical oxidative-stress model of neurotoxicity
in Alzheimer's disease (AD) has received much attention recently. In this study, we have …

Alzheimer's amyloid-β as a preventive antioxidant for brain lipoproteins

A Kontush - Cellular and molecular neurobiology, 2001 - Springer
Increased production of Aβ in a form of lipoprotein antioxidant under the action of increased
oxidative stress in aging with subsequent chelation of transition metal ions by Aβ …

Vitamin E binding protein A famin Protects Neuronal Cells in vitro

M Heiser, B Hutter-Paier, L Jerkovic, R Pfragner… - Ageing and Dementia …, 2002 - Springer
Afamin, an 87kDa human plasma glycoprotein with specific binding properties for vitamin E
(a-tocopherol) was recently characterized ([Jerkovic, 1997];[Vögele, 1999]). In the present …

Aβ [25–35] peptide and iron promote apoptosis in lymphocytes by an oxidative stress mechanism: involvement of H2O2, caspase-3, NF-κB, p53 and c-Jun

C Velez-Pardo, GG Ospina, MJ del Rio - Neurotoxicology, 2002 - Elsevier
The Aβ deposition in the neuritic plaques is one of the major neuropathological hallmarks of
the Alzheimer disease (AD). Studies in vitro have demonstrated that the Aβ25–35 fragment …

Coumarin derivatives protection against ROS production in cellular models of Aβ toxicities

CA Kontogiorgis, Y Xu, D Hadjipavlou-Litina… - Free radical …, 2007 - Taylor & Francis
The role of oxidative stress and free radicals in the development of Alzheimer's disease (AD)
has been the focus of many recent studies. The role of hydrogen peroxide (H2O2) in AD is …

[PDF][PDF] La apoptosis en las enfermedades neurodegenerativas: evidencias y controversias

MJ del Río, C Vélez-Pardo - Rev Neurol, 2001 - researchgate.net
APOPTOSIS IN NEURODEGENERATIVE DISEASES: FACTS AND CONTROVERSIES
Summary. Objectives. In this article, the authors analyzed critically the morphological and …

[图书][B] Oxidative stress and age-related neurodegeneration

Y Luo - 2005 - books.google.com
Oxidative Stress and Age-Related Neurodegeneration brings together researchers from a
variety of fields to compare normal aging and disease-related neurodegeneration in terms of …

New Lipoxygenase Inhibitors of Reactive Oxygen Species Production in Cellular Models of Amyloid (A 2) Toxicities

E Pontiki, C Kontogiorgis, Y Xu… - Journal of …, 2013 - content.iospress.com
Neuroinflammation and oxidative stress are contributing factors to neurodegeneration in
physiological aging as well as in age-related neurological disorders. Neuroinflammation can …

[图书][B] Modulation of stress responses and attenuation of oxidative free radicals in Alzheimer's disease models by the Ginkgo biloba extract EGb 761

JV Smith - 2004 - search.proquest.com
The prevalence of Alzheimer's disease (AD) among the public has reached shocking levels,
striking those around us with alarming frequency. This debilitating disease, capable of …