The prognostication of colorectal cancer (CRC) has traditionally relied on staging as defined
by the Union for International Cancer Control (UICC) and American Joint Committee on …

The number of molecularly stratified treatment options available to patients with colorectal
cancer (CRC) is increasing, with a parallel rise in the use of biomarkers to guide …

Objectives: To develop evidence-based guideline recommendations through a systematic
review of the literature to establish standard molecular biomarker testing of colorectal cancer …

Colorectal cancer (CRC) is a leading cause of death worldwide, despite progress made in
detection and management through surgery, chemotherapy, radiotherapy, and …

Colorectal cancer (CRC) is a leading cause of death among cancer patients. This
heterogeneous disease is characterized by alterations in multiple molecular pathways …

The association between mutations of key driver genes and colorectal cancer (CRC)
metastasis has been investigated by many studies. However, the results of these studies …

Abstract PI3K/AKT signaling leads to reduced apoptosis, stimulates cell growth and
increases proliferation. Under normal conditions, PI3K/AKT activation is tightly controlled …

The colon is derived from the embryological midgut and hindgut separately, with the right
colon and left colon having different features with regards to both anatomical and …

Identifying putative biomarkers of clinical outcomes in cancer is crucial for successful
enrichment, and for the selection of patients who are the most likely to benefit from a specific …

Phosphatase and TENsin homolog deleted on chromosome 10 (PTEN) is a tumor
suppressor gene located at chromosome 10q23. 31, encoding for a 403-amino acid protein …