Towards artificial intelligence-enabled extracellular vesicle precision drug delivery

ZF Greenberg, KS Graim, M He - Advanced Drug Delivery Reviews, 2023 - Elsevier
Abstract Extracellular Vesicles (EVs), particularly exosomes, recently exploded into
nanomedicine as an emerging drug delivery approach due to their superior biocompatibility …

Extracellular vesicles in pancreatic cancer immune escape: emerging roles and mechanisms

C Liu, D He, L Li, S Zhang, L Wang, Z Fan… - Pharmacological …, 2022 - Elsevier
Pancreatic cancer (PC) is the most lethal malignancy worldwide due to its delayed diagnosis
and limited treatment options. Despite great progress in clinical trials of immunotherapies for …

Lipid-based nanovesicular drug delivery systems

T Limongi, F Susa, M Marini, M Allione, B Torre… - Nanomaterials, 2021 - mdpi.com
In designing a new drug, considering the preferred route of administration, various
requirements must be fulfilled. Active molecules pharmacokinetics should be reliable with a …

Exosome membrane-coated nanosystems: Exploring biomedical applications in cancer diagnosis and therapy

M Shao, D Lopes, J Lopes, S Yousefiasl… - Matter, 2023 - cell.com
Bio-mimicking principles have recently been proposed for the surface functionalization of
nanoparticles (NPs). Such a strategy is based on camouflaging the NP surface with …

Extracellular vesicles: A new diagnostic biomarker and targeted drug in osteosarcoma

X Gao, B Gao, S Li - Frontiers in Immunology, 2022 - frontiersin.org
Osteosarcoma (OS) is a primary bone cancer that is highly prevalent among adolescents
and adults below the age of 20 years. The prognostic outcome of metastatic OS or relapse is …

Glioblastoma cell-derived exosomes functionalized with peptides as efficient nanocarriers for synergistic chemotherapy of glioblastoma with improved biosafety

Y Zhou, L Wang, L Chen, W Wu, Z Yang, Y Wang… - Nano Research, 2023 - Springer
Glioblastoma (GBM) has been regarded as one of the most deadly and challenging cancers
to treat with extremely poor prognosis. The limited efficacy of current chemotherapies might …

[HTML][HTML] Functions and therapeutic potentials of exosomes in osteosarcoma

J Yue, ZS Chen, XX Xu, S Li - Acta materia medica, 2022 - ncbi.nlm.nih.gov
Osteosarcoma is a primary malignant tumor of the skeleton with the morbidity of 2.5 in 1
million. The regularly on-set is in the epiphysis of the extremities with a high possibility of …

Engineered Extracellular vesicles as a targeted delivery platform for Precision Therapy

Y Sun, F Sun, W Xu, H Qian - Tissue Engineering and Regenerative …, 2023 - Springer
Extracellular vesicles (EVs)-based cell-free strategy has shown therapeutic potential in
tissue regeneration. Due to their important roles in intercellular communications and their …

[HTML][HTML] Cellular nanovesicles for therapeutic immunomodulation: A perspective on engineering strategies and new advances

E Zhang, P Phan, Z Zhao - Acta Pharmaceutica Sinica B, 2023 - Elsevier
Cellular nanovesicles which are referred to as cell-derived, nanosized lipid bilayer
structures, have emerged as a promising platform for regulating immune responses. Owing …

Recent progresses of exosome–liposome fusions in drug delivery

L Zheng, B Hu, D Zhao, W Liu, Q Liu, Y Huang… - Chinese Chemical …, 2024 - Elsevier
Exosomes are membrane-bound nanoscale extracellular vesicles, which produced by
almost all organisms. Due to the excellent biocompatibility, long circulation time as well as …