The past decade has seen the emergence of immunotherapy as a prime approach to cancer
treatment, revolutionizing the management of many types of cancer. Despite the promise of …

Chromatin, the physiological template of all eukaryotic genetic information, is subject to a
diverse array of posttranslational modifications that largely impinge on histone amino …

Epigenetic mechanisms, which involve DNA and histone modifications, result in the
heritable silencing of genes without a change in their coding sequence. The study of human …

The expression of genes is regulated at many levels. Perhaps the area in which least is
known is how nuclear organization influences gene expression. Studies of higher-order …

Lysyl oxidase (LO) plays a critical role in the formation and repair of the extracellular matrix
(ECM) by oxidizing lysine residues in elastin and collagen, thereby initiating the formation of …

Post-translational addition of methyl groups to the amino-terminal tails of histone proteins
was discovered more than three decades ago. Only now, however, is the biological …

Over the past few years, HLA-G, the non-classical HLA class I molecule, has been the center
of investigations that have led to the description of its specific structural and functional …

The treatment of cancer through the development of new therapies is one of the most
important challenges of our time. The decoding of the human genome has yielded important …

The reversible histone acetylation and deacetylation are epigenetic phenomena that play
critical roles in the modulation of chromatin topology and the regulation of gene expression …

Emerging evidence suggests that poor glycemic control mediates post-translational
modifications to the H3 histone tail. We are only beginning to understand the dynamic role of …