Cytokine loci undergo changes in chromatin structure when naive CD4+ T cells differentiate
into Th1 or Th2 cells and have also been examined for regulatory sequences underlying …

Transcriptional repression of methylated genes can be mediated by the methyl-CpG binding
protein MeCP2. Here we show that human Brahma (Brm), a catalytic component of the …

EBV latent membrane protein 1 (LMP1) activates cellular DNA methyltransferases, resulting
in hypermethylation and silencing of E-cadherin. However, the underlying mechanism …

Acetylation of histone core particles plays an important role in modulating chromatin
structure and gene expression. The acetylation status of the histone tails is determined by …

Identification of genes predisposing their carrier to complex diseases is a much more
complicated task than finding genes involved in simple mendelian diseases. The slow …

Learning Objectives After completing this course, the reader will be able to: Describe the
role of epigenetic information in the regulation of gene expression and in the development of …

Epigenetic regulation of gene expression occurs due to alterations in chromatin proteins that
do not change DNA sequence, but alter the chromatin architecture and the accessibility of …

Gender differences in susceptibility to complex disease such as asthma, diabetes, lupus,
autism and major depression, among numerous other disorders, represent one of the …

In Down's syndrome there is evidence that increased gene expression coding for specific
cystathionine beta-synthase translates directly into biochemical aberrations, which result in …

Knowledge of the molecular events that occur during the early stages of cancer has
advanced rapidly. The initiation and development of cancer involves several molecular …