Endocannabinoid signalling in reward and addiction

LH Parsons, YL Hurd - Nature Reviews Neuroscience, 2015 - nature.com
Brain endocannabinoid (eCB) signalling influences the motivation for natural rewards (such
as palatable food, sexual activity and social interaction) and modulates the rewarding effects …

Co-use of alcohol and cannabis: A review

AM Yurasek, ER Aston, J Metrik - Current addiction reports, 2017 - Springer
Abstract Purpose of Review The purpose of this review is to provide an overview of the
existing literature on the relationship between the co-use of cannabis and alcohol including …

Alcohol use disorder and sleep disturbances: a feed-forward allostatic framework

GF Koob, IM Colrain - Neuropsychopharmacology, 2020 - nature.com
The development of alcohol use disorder (AUD) involves binge or heavy drinking to high
levels of intoxication that leads to compulsive intake, the loss of control in limiting intake, and …

The neurobiology of social play and its rewarding value in rats

LJMJ Vanderschuren, EJM Achterberg… - … & Biobehavioral Reviews, 2016 - Elsevier
In the young of many mammalian species, including humans, a vigorous and highly
rewarding social activity is abundantly expressed, known as social play behaviour. Social …

[HTML][HTML] Patterns of cannabis and alcohol co-use: Substitution versus complementary effects

RL Gunn, ER Aston, J Metrik - Alcohol Research: Current Reviews, 2022 - ncbi.nlm.nih.gov
PURPOSE The purpose of this review is to discuss the literature regarding the concurrent
use (co-use) of alcohol and cannabis and competing hypotheses as to whether cannabis …

Integrated treatment of substance use and psychiatric disorders

TM Kelly, DC Daley - Social work in public health, 2013 - Taylor & Francis
Epidemiological studies find that psychiatric disorders, including mental disorders and
substance use disorders, are common among adults and highly comorbid. Integrated …

[HTML][HTML] Lipids in psychiatric disorders and preventive medicine

M Schneider, B Levant, M Reichel, E Gulbins… - Neuroscience & …, 2017 - Elsevier
Psychiatric disorders like mood disorders, schizophrenia, or drug addiction affect a sizeable
proportion of the human population and severely compromise quality of life. Therefore …

Medicinal Chemistry, Pharmacology, and Potential Therapeutic Benefits of Cannabinoid CB2 Receptor Agonists

M Aghazadeh Tabrizi, PG Baraldi, PA Borea… - Chemical …, 2016 - ACS Publications
The endocannabinoid system is represented by a group of neuromodulatory lipids and their
receptors that are involved in a variety of physiological and pathological conditions. The …

Common single nucleotide variants underlying drug addiction: more than a decade of research

KM Bühler, E Giné, V Echeverry‐Alzate… - Addiction …, 2015 - Wiley Online Library
Drug‐related phenotypes are common complex and highly heritable traits. In the last few
years, candidate gene (CGAS) and genome‐wide association studies (GWAS) have …

A model of Δ9-tetrahydrocannabinol self-administration and reinstatement that alters synaptic plasticity in nucleus accumbens

S Spencer, D Neuhofer, VC Chioma, C Garcia-Keller… - Biological …, 2018 - Elsevier
Background Cannabis is the most widely used illicit drug, but knowledge of the neurological
consequences of cannabis use is deficient. Two primary components of cannabis are Δ 9 …