Polyploid cells demonstrate biological plasticity and stress adaptation in evolution;
development; and pathologies, including cardiovascular diseases, neurodegeneration, and …

Pancreatic cancer is one of the most aggressive cancers worldwide due to the resistances to
conventional therapies and early metastasis. Recent research has shown that cancer stem …

The expression of gametogenesis-related (GG) genes and proteins, as well as whole
genome duplications (WGD), are the hallmarks of cancer related to poor prognosis …

Precision and organization govern the cell cycle, ensuring normal proliferation. However,
some cells may undergo abnormal cell divisions (neosis) or variations of mitotic cycles …

3 This correspondence to Gene & Diseases calls attention to the controversy between 4
proponents of genetic modification in carcinogenesis and supporters of non-mutational 5 …

The global burden of cancer incidence, deaths and economic costs is steadily increasing
since several decades. Despite a massive allocation of research funds since the 1970s, no …

B-Raf kinase inhibitors such as vemurafenib (PLX4032) and dabrafenib have limited
therapeutic efficacy on BRAF-mutated thyroid cancer. Cancer stem cells (CSCs) play …

Oncogenesis and the origin of cancer are still not fully understood despite the efforts of
histologists, pathologists, and molecular geneticists to determine how cancer develops …

Many cardiovascular diseases originate from growth retardation, inflammation, and
malnutrition during early postnatal development. The nature of this phenomenon is not …

From an evolutionary perspective, the human cancer genome is based on an ancient gene
module developed by the common ancestor of the Amoebozoa, Metazoa, and Fungi (AMF) …