The sodium/iodide symporter (NIS): molecular physiology and preclinical and clinical applications

S Ravera, A Reyna-Neyra, G Ferrandino… - Annual review of …, 2017 - annualreviews.org
Active iodide (I−) transport in both the thyroid and some extrathyroidal tissues is mediated by
the Na+/I− symporter (NIS). In the thyroid, NIS-mediated I− uptake plays a pivotal role in …

Defects in protein folding in congenital hypothyroidism

HM Targovnik, KG Scheps, CM Rivolta - Molecular and cellular …, 2020 - Elsevier
Primary congenital hypothyroidism (CH) is the most common endocrine disease in children
and one of the most common preventable causes of both cognitive and motor deficits. CH is …

Thyroid disease and the nervous system

CA Wood-Allum, PJ Shaw - Handbook of clinical neurology, 2014 - Elsevier
Thyroid disorders are common in the general population and in hospitalized patients.
Thyroid disease may present first with neurological complications or else may occur …

[HTML][HTML] Clinical use of thyroglobulin: not only thyroid cancer

B Agata, ŚS Renata - Endocrine, 2024 - Springer
Thyroglobulin (TG) is a dimeric glycoprotein produced exclusively by mature thyroid tissue
and stored within the follicular lumen. It is essential for the organification of iodine and the …

[HTML][HTML] Insights into the posttranslational structural heterogeneity of thyroglobulin and its role in the development, diagnosis, and management of benign and …

ACW Xavier, RMB Maciel, JGH Vieira… - … of endocrinology and …, 2016 - SciELO Brasil
Thyroglobulin (Tg) is the major glycoprotein produced by the thyroid gland, where it serves
as a template for thyroid hormone synthesis and as an intraglandular store of iodine …

Thyroglobulin gene mutations in Chinese patients with congenital hypothyroidism

X Hu, R Chen, C Fu, X Fan, J Wang, J Qian, S Yi… - Molecular and Cellular …, 2016 - Elsevier
Mutations in Thyroglobulin (TG) are common genetic causes of congenital hypothyroidism
(CH). But the TG mutation spectrum and its frequency in Chinese CH patients have not been …

Actualización en hipotiroidismo congénito: etiología, cuadro clínico, diagnóstico y tratamiento. Segunda parte.

A Rivera-Hernández… - Revista Mexicana …, 2018 - search.ebscohost.com
En esta segunda parte se abordarán los aspectos del hipotiroidismo congénito (HC): su
etiología, cuadro clínico, diagnóstico, tratamiento y seguimiento. El HC se clasifica, por su …

Cellular and molecular distribution of thyroid-specific proteins, thyroid-stimulating hormone receptor (TSH-R) and thyroglobulin (TG) in the central nervous system

M Naicker, S Naidoo - Neurochemistry International, 2022 - Elsevier
The widespread extra-thyroidal localisation of thyroid-specific proteins, thyroid-stimulating
hormone receptor (TSH-R) and thyroglobulin (TG), has been well documented. However …

[HTML][HTML] Habilidades do desenvolvimento em crianças com hipotireoidismo congênito: enfoque na comunicação

MG Gejão, DAC Lamônica - Pró-Fono Revista de Atualização …, 2008 - SciELO Brasil
TEMA: o hipotireoidismo congênito pode acarretar alterações no desenvolvimento global
infantil. OBJETIVO: traçar o perfil do desenvolvimento em crianças com hipotireoidismo …

[HTML][HTML] Congenital thyroid hypoplasia and seizures in 2 littermate kittens

AM Traas, BL Abbott, A French… - Journal of veterinary …, 2008 - ncbi.nlm.nih.gov
Two male littermate kittens (Kitten A and B) were examined at 14 weeks of age because of
straining to defecate in the litter box. According to the owner neither kitten was seen having …