Lipids constitute the bulk of the dry mass of the brain and have been associated with healthy
function as well as the most common pathological conditions of the brain. Demographic …

Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis with
associated frontotemporal dementia (ALS/FTD) are major neurodegenerative diseases for …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an estimated
heritability between 40 and 50%. DNA methylation patterns can serve as proxies of (past) …

In Parkinson's disease (PD), α-synuclein (αS) pathologically impacts the brain, a highly lipid-
rich organ. We investigated how alterations in αS or lipid/fatty acid homeostasis affect each …

Objective To identify shared polygenic risk and causal associations in amyotrophic lateral
sclerosis (ALS). Methods Linkage disequilibrium score regression and Mendelian …

Parkinson's disease (PD) is a neurodegenerative disease due to the degeneration of
dopaminergic neurons (DNs) in the substantia nigra (SN). The liver X receptor (LXR) is …

Neurodegenerative diseases are conventionally demarcated as disorders with selective loss
of neurons. Conventional as well as newer molecules have been tested but they offer just …

Many neurodegenerative diseases are rooted in the activities of amyloid-like proteins which
possess conformations that spread to healthy proteins. These include Alzheimer's disease …

Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disorder that is
predicted to increase across the globe by~ 70% in the following decades. Understanding the …

Amyotrophic lateral sclerosis (ALS) is characterized by progressive loss of upper and lower
motor neurons leading to muscle paralysis and death. While a link between dysregulated …