Mutations of CX46/CX50 and cataract development

Y Shi, X Li, J Yang - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Cataract is a common disease in the aging population. Gap junction has been considered a
central component in maintaining homeostasis for preventing cataract formation. Gap …

Traumatic brain injury and blood-brain barrier cross-talk

M Nasser, F Bejjani, M Raad… - CNS & Neurological …, 2016 - ingentaconnect.com
Traumatic brain injury, often referred to as the “silent epidemic,” is a nondegenerative, non-
congenital insult to the brain due to a blow or penetrating object that disrupts the function of …

Differential connexin function enhances self-renewal in glioblastoma

M Hitomi, LP Deleyrolle, EE Mulkearns-Hubert, A Jarrar… - Cell reports, 2015 - cell.com
The coordination of complex tumor processes requires cells to rapidly modify their
phenotype and is achieved by direct cell-cell communication through gap junction channels …

Altered ubiquitin causes perturbed calcium homeostasis, hyperactivation of calpain, dysregulated differentiation, and cataract

K Liu, L Lyu, D Chin, J Gao, X Sun… - Proceedings of the …, 2015 - National Acad Sciences
Although the ocular lens shares many features with other tissues, it is unique in that it retains
its cells throughout life, making it ideal for studies of differentiation/development …

[HTML][HTML] Molecular and structural analysis of genetic variations in congenital cataract

M Kumar, T Agarwal, P Kaur, S Khokhar… - Molecular vision, 2013 - ncbi.nlm.nih.gov
Objective To determine the relative contributions of mutations in congenital cataract cases in
an Indian population by systematic screening of genes associated with cataract. Methods …

Role and posttranslational regulation of Cx46 hemichannels and gap junction channels in the eye lens

MA Retamal, GA Altenberg - Frontiers in Physiology, 2022 - frontiersin.org
Connexins are a family of proteins that can form two distinct types of channels:
hemichannels and gap junction channels. Hemichannels are composed of six connexin …

Membrane channel gene expression in human costal and articular chondrocytes

A Asmar, R Barrett-Jolley, A Werner, R Kelly Jr… - …, 2016 - Taylor & Francis
Chondrocytes are the uniquely resident cells found in all types of cartilage and key to their
function is the ability to respond to mechanical loads with changes of metabolic activity. This …

Complementary expression and phosphorylation of Cx46 and Cx50 during development and following gene deletion in mouse and in normal and orchitic mink testes

RM Pelletier, CD Akpovi, L Chen… - American Journal …, 2015 - journals.physiology.org
Gap junction-mediated communication helps synchronize interconnected Sertoli cell
activities. Besides, coordination of germ cell and Sertoli cell activities depends on gap …

KI04 an Aminoglycosides-Derived Molecule Acts as an Inhibitor of Human Connexin46 Hemichannels Expressed in HeLa Cells

CWT Chang, N Poudyal, DA Verdugo, F Peña… - Biomolecules, 2023 - mdpi.com
Background: Connexins (Cxs) are proteins that help cells to communicate with the
extracellular media and with the cytoplasm of neighboring cells. Despite their importance in …

Oxygen sensitivity of placental trophoblast connexins 43 and 46: a role in preeclampsia?

T Otto, A Gellhaus, N Lüschen… - Journal of Cellular …, 2015 - Wiley Online Library
Several gap junction connexins have been shown to be essential for appropriate placental
development and function. It is known that the expression and distribution of connexins …