[HTML][HTML] β-lactam Resistance in Pseudomonas aeruginosa: Current Status, Future Prospects

KA Glen, IL Lamont - Pathogens, 2021 - mdpi.com
Pseudomonas aeruginosa is a major opportunistic pathogen, causing a wide range of acute
and chronic infections. β-lactam antibiotics including penicillins, carbapenems …

Pseudomonas aeruginosa elastase (LasB) as a therapeutic target

MJ Everett, DT Davies - Drug Discovery Today, 2021 - Elsevier
The Pseudomonas aeruginosa LasB elastase (elastase B, pseudolysin) is the predominant
protease in the P. aeruginosa secretome. It has been shown to hydrolyse a vast array of host …

Facial amphiphilic naphthoic acid-derived antimicrobial polymers against multi-drug resistant gram-negative bacteria and biofilms

LB Kurnaz, S Barman, X Yang, C Fisher, FW Outten… - Biomaterials, 2023 - Elsevier
Inspired by the facial amphiphilic nature and antimicrobial efficacy of many antimicrobial
peptides, this work reported facial amphiphilic bicyclic naphthoic acid derivatives with …

Real-time monitoring of Pseudomonas aeruginosa biofilm growth dynamics and persister cells' eradication

M Žiemytė, M Carda-Diéguez… - Emerging Microbes & …, 2021 - Taylor & Francis
Biofilm formation and the appearance of persister cells with low metabolic rates are key
factors affecting conventional treatment failure and antibiotic resistance. Using impedance …

Targeting multidrug-recalcitrant pseudomonas aeruginosa biofilms: combined-enzyme treatment enhances antibiotic efficacy

Y Zhang, W Wei, H Wen, Z Cheng, Z Mi… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
Pseudomonas aeruginosa is an opportunistic pathogen that forms biofilms during infection,
resulting in recalcitrance to antibiotic treatment. Biofilm inhibition is a promising research …

Chemical Optimization of Selective Pseudomonas aeruginosa LasB Elastase Inhibitors and Their Impact on LasB-Mediated Activation of IL-1β in Cellular and Animal …

MJ Everett, DT Davies, S Leiris, N Sprynski… - ACS Infectious …, 2023 - ACS Publications
LasB elastase is a broad-spectrum exoprotease and a key virulence factor of Pseudomonas
aeruginosa, a major pathogen causing lung damage and inflammation in acute and chronic …

Assessment of virulence factors and antimicrobial resistance among the Pseudomonas aeruginosa strains isolated from animal meat and carcass samples

S Poursina, M Ahmadi, F Fazeli… - Veterinary medicine and …, 2023 - Wiley Online Library
Background Pseudomonas aeruginosa bacteria are emerging causes of food spoilage and
foodborne diseases. Raw meat of animal species may consider a reservoir of P. aeruginosa …

[HTML][HTML] Inhibition of the Quorum Sensing System, Elastase Production and Biofilm Formation in Pseudomonas aeruginosa by Psammaplin A and Bisaprasin

ET Oluwabusola, NP Katermeran, WH Poh, TMB Goh… - Molecules, 2022 - mdpi.com
Natural products derived from marine sponges have exhibited bioactivity and, in some
cases, serve as potent quorum sensing inhibitory agents that prevent biofilm formation and …

[HTML][HTML] Genome Analysis of Pseudomonas aeruginosa Strains from Chronically Infected Patients with High Levels of Persister Formation

AA Baiomy, FE Serry, AA Kadry, G Yahya, S Doijad… - Pathogens, 2023 - mdpi.com
The appearance of persister cells with low metabolic rates are key factors leading to
antibiotic treatment failure. Such persisters are multidrug tolerant and play a key role in the …

Pseudomonas aeruginosa strains from both clinical and environmental origins readily adopt a stable small-colony-variant phenotype resulting from single mutations in …

A Besse, MC Groleau, M Trottier, AT Vincent… - Journal of …, 2022 - Am Soc Microbiol
ABSTRACT A subpopulation of small-colony variants (SCVs) is a frequently observed
feature of Pseudomonas aeruginosa isolates obtained from colonized cystic fibrosis lungs …