Hyperlipidemia, also known as high blood cholesterol, is a cardiovascular health risk that
affects more than one third of adults in the United States. Statins are commonly prescribed …

There has been increasing awareness of the adverse effects of therapeutic agents and
exogenous toxins on the structure and function of muscle. The resulting clinical syndrome …

Objective Our objective was to investigate the interactions between common polymorphisms
in ABCB1, CYP3A4, and CYP3A5 genes and the lipid‐lowering efficacy and safety of the 3 …

The benefits of lipid lowering therapy on coronary heart disease have been clearly
established in many clinical trials on primary and secondary prevention. Despite the …

Aims: To investigate the effects of antacid suspension on oral absorption of itraconazole.
Methods: A randomized, open‐labelled, two‐period, crossover study with a 1‐week washout …

Aims To evaluate whether simvastatin influences (i) the intestinal expression of P‐
glycoprotein (P‐gp) and MRP2, and (ii) the disposition of the β1‐selective blocker talinolol, a …

Each of the lipid-lowering agents available today can cause myopathy. The severity of the
muscle disorder may vary from trivial myalgias or elevations of creatine kinase in …

Modulation of intestinal drug absorption barriers can have a profound impact on the
bioavailability of orally administered compounds. With its commonality of use as an …

This edition of the Med-Psych Drug-Drug Interactions Update begins a change in format.
Starting with this column, each column will feature one drug-drug interaction (DDI) topic that …

Objetivo Determinar en el ámbito de atención primaria la frecuencia de potenciales
interacciones farmacológicas de las estatinas. Diseño Estudio observacional transversal …