In this study, we assess on a large scale the possibility of deriving self‐inhibitory peptides
from protein domains with globular architectures. Such inhibitory peptides would inhibit …

T cell immune responses are driven by the recognition of peptide antigens (T cell epitopes)
that are bound to major histocompatibility complex (MHC) molecules. T cell epitope …

Peptide-protein interactions are ubiquitous in the cell and form an important part of the
interactome. Computational docking methods can complement experimental …

Understanding the mechanisms involved in the activation of an immune response is
essential to many fields in human health, including vaccine development and personalized …

Highlights•Accrual of peptide–protein complex structures allowed their detailed
characterization.•This has lead to rapid progress in peptide docking, based on diverse …

The class I proteins of the major histocompatibility complex (MHC-I) display epitopic
peptides derived from endogenous proteins on the cell surface for immune surveillance …

Protein–protein recognition, frequently mediated by members of large families of interaction
domains, is one of the cornerstones of biological function. Here, we present a computational …

T-cell recognition of peptide/major histocompatibility complex (MHC) is a prerequisite for
cellular immunity. Recently, there has been an influx of bioinformatics tools to facilitate the …

Motivation: Design of protein–protein interaction (PPI) inhibitors is a key challenge in
structural bioinformatics and computer-aided drug design. Peptides, which partially mimic …

Most therapeutic proteins in clinical trials or on the market are, to a variable extent,
immunogenic. Formation of antidrug antibodies poses a risk that should be assessed during …