Introduction: Cancer neoantigens represent important targets of cancer immunotherapy. The
goal of cancer neoantigen vaccines is to induce neoantigen-specific immune responses and …

In the last years, immunotherapies have shown tremendous success as treatments for
multiple types of cancer. However, there are still many obstacles to overcome in order to …

With the decline in productivity of drug‐development efforts, novel approaches to rational
drug design are being introduced and developed. Naturally occurring and synthetic peptides …

The huge conformational space stemming from the inherent flexibility of peptides is among
the main obstacles to successful and efficient computational modeling of protein-peptide …

The class I major histocompatibility complex (MHC) is capable of binding peptides derived
from intracellular proteins and displaying them at the cell surface. The recognition of these …

Biological metabolites, substrates, cofactors, chemical probes, and drugs bind to flexible
pockets in multiple biological macromolecules to exert their biological effect. The rapid …

The immune system is constantly challenged, being required to protect the organism against
a wide variety of infectious pathogens and, at the same time, to avoid autoimmune disorders …

The interaction between T-cell receptors (TCRs) and major histocompatibility complex
(MHC)-bound epitopes is one of the most important processes in the adaptive human …

The immune system is constantly protecting its host from the invasion of pathogens and the
development of cancer cells. The specific CD8+ T-cell immune response against virus …

Motivation: The binding of endogenous antigenic peptides to MHC class I molecules is an
important step during the immunologic response of a host against a pathogen. Thus, various …