Prediction of peptide binding to human leukocyte antigen (HLA) molecules is essential to a
wide range of clinical entities from vaccine design to stem cell transplant compatibility. Here …

The immune system is engaged in a constant antigenic surveillance through the Major
Histocompatibility Complex (MHC) class I antigen presentation pathway. This is an efficient …

PURPOSE HLA protein receptors play a key role in cellular immunity. They bind intracellular
peptides and display them for recognition by T-cell lymphocytes. Because T-cell activation is …

Major Histo-Compatibility (MHC) class I molecules are major agents of the mammalian
adaptive immune system. Class I molecules bind short antigenic peptides with a length of 8 …

The CrossTope is a highly curate repository of three-dimensional structures of peptide:
major histocompatibility complex (MHC) class I complexes (pMHC-I). The complexes hosted …

Peptide–protein interactions are prevalent in the living cell and form a key component of the
overall protein–protein interaction network. These interactions are drawing increasing …

The binding of peptide fragments of antigens to class II MHC proteins is a crucial step in
initiating a helper T cell immune response. The discovery of these peptide epitopes is …

Staphylococcus aureus infection is a major public health threat in part due to the spread of
antibiotic resistance and repeated failures to develop a protective vaccine. Infection is …

MHC class I molecules govern human cytotoxic T cell responses. Their specificity
determines which peptides they sample from the intracellular protein environment and then …

The structurally unique amino-terminal domain of class II G protein-coupled receptors is
critically important for ligand binding and receptor activation. Understanding the precise role …