DNA Synthesis Past a 5-MethylC-Containing cis-syn-Cyclobutane Pyrimidine Dimer by Yeast Pol η Is Highly Nonmutagenic
B Vu, VJ Cannistraro, L Sun, JS Taylor - Biochemistry, 2006 - ACS Publications
Cyclobutane pyrimidine dimers (CPDs) are responsible for a considerable fraction of
sunlight-induced C to T and 5-methycytosine (mC) to T mutations in mammalian cells …
sunlight-induced C to T and 5-methycytosine (mC) to T mutations in mammalian cells …
In vivo DNA analysis
R Drouin, JP Therrien, M Angers, S Ouellet - DNA-Protein Interactions …, 2001 - Springer
The in vivo analysis of DNA-protein interactions and chromatin structure can provide several
kinds of critical information regarding regulation of gene expression and gene function. For …
kinds of critical information regarding regulation of gene expression and gene function. For …
Skin tumours induced by narrowband UVB have higher frequency of p53 mutations than tumours induced by broadband UVB independent of Ogg1 genotype
F Yogianti, M Kunisada, R Ono, K Sakumi… - …, 2012 - academic.oup.com
Different wavelengths of ultraviolet (UV) light have different promoting effects on skin
carcinogenesis. Narrowband UVB (NB-UVB) has a single-peak wavelength of 311nm and is …
carcinogenesis. Narrowband UVB (NB-UVB) has a single-peak wavelength of 311nm and is …
The yeast p53 functional assay: a new tool for molecular epidemiology. Hopes and facts
G Fronza, A Inga, P Monti, G Scott… - … Research/Reviews in …, 2000 - Elsevier
The assumption of molecular epidemiology that carcinogens leave fingerprints has
suggested that analysis of the frequency, type, and site of mutations in genes frequently …
suggested that analysis of the frequency, type, and site of mutations in genes frequently …
Simulated sunlight and benzo[ a ]pyrene diol epoxide induced mutagenesis in the human p53 gene evaluated by the yeast functional assay: lack of …
JH Yoon, CS Lee, GP Pfeifer - Carcinogenesis, 2003 - academic.oup.com
Many mutations in the p53 gene destroy the transcriptional transactivation function of the
p53 protein. This function of p53 can be determined in a yeast assay using a p53 responsive …
p53 protein. This function of p53 can be determined in a yeast assay using a p53 responsive …
NR4A2 promotes DNA double-strand break repair upon exposure to UVR
Exposure of melanocytes to ultraviolet radiation (UVR) induces the formation of UV lesions
that can produce deleterious effects in genomic DNA. Encounters of replication forks with …
that can produce deleterious effects in genomic DNA. Encounters of replication forks with …
In vivo protein‐DNA interactions at the kinin B1 receptor gene promoter: No modification on interleukin‐1 beta or lipopolysaccharide induction
M Angers, R Drouin, M Bachvarova… - Journal of cellular …, 2000 - Wiley Online Library
The kinin B1 receptor (B1R) gene is strongly upregulated following tissue injury and
inflammation. In an attempt to define the regulatory elements that account for the control of …
inflammation. In an attempt to define the regulatory elements that account for the control of …
In Vivo Spectrum of UVC‐induced Mutation in Mouse Skin Epidermis May Reflect the Cytosine Deamination Propensity of Cyclobutane Pyrimidine Dimers
H Ikehata, T Mori, M Yamamoto - Photochemistry and …, 2015 - Wiley Online Library
Although ultraviolet radiation (UVR) has a genotoxicity for inducing skin cancers, the skin
may tolerate UVC component because the epidermal layer prevents this short wavelength …
may tolerate UVC component because the epidermal layer prevents this short wavelength …
Chemoprevention of skin cancer through natural agents
To reduce the occurrence of skin cancers, the use of sunscreens and wearing protective
clothing while in the sun are emphasized. These are important strategies, but sadly these …
clothing while in the sun are emphasized. These are important strategies, but sadly these …
Solar-UV-signature mutation prefers TCG to CCG: extrapolative consideration from UVA1-induced mutation spectra in mouse skin
H Ikehata, J Kumagai, T Ono, A Morita - Photochemical & Photobiological …, 2013 - Springer
UVA1 exerts its genotoxicity on mammalian skin by producing cyclobutane pyrimidine
dimers (CPDs) in DNA and preferentially inducing solar-UV-signature mutations, C? T base …
dimers (CPDs) in DNA and preferentially inducing solar-UV-signature mutations, C? T base …