Roles and mechanisms of dipeptidyl peptidase 4 inhibitors in vascular aging
F Cao, K Wu, YZ Zhu, ZW Bao - Frontiers in Endocrinology, 2021 - frontiersin.org
Vascular aging is characterized by alterations in the constitutive properties and biological
functions of the blood vessel wall. Endothelial cells (ECs) and vascular smooth muscle cells …
functions of the blood vessel wall. Endothelial cells (ECs) and vascular smooth muscle cells …
The role of dipeptidylpeptidase-4 inhibitors in management of cardiovascular disease in diabetes; focus on linagliptin
AR Aroor, C Manrique-Acevedo… - Cardiovascular diabetology, 2018 - Springer
Multiple population based analyses have demonstrated a high incidence of cardiovascular
disease (CVD) and cardiovascular (CV) mortality in subjects with T2DM that reduces life …
disease (CVD) and cardiovascular (CV) mortality in subjects with T2DM that reduces life …
[PDF][PDF] Endothelin and diabetic complications: a brain-centric view
The global epidemic of diabetes is of significant concern. Diabetes associated vascular
disease signifies the principal cause of morbidity and mortality in diabetic patients. It is also …
disease signifies the principal cause of morbidity and mortality in diabetic patients. It is also …
Endothelial dysfunction in vascular complications of diabetes: a comprehensive review of mechanisms and implications
DR Yang, MY Wang, CL Zhang, Y Wang - Frontiers in Endocrinology, 2024 - frontiersin.org
Diabetic vascular complications are prevalent and severe among diabetic patients,
profoundly affecting both their quality of life and long-term prospects. These complications …
profoundly affecting both their quality of life and long-term prospects. These complications …
The dipeptidyl peptidase-4 inhibitor linagliptin ameliorates high-fat induced cognitive decline in tauopathy model mice
Y Nakaoku, S Saito, Y Yamamoto, T Maki… - International Journal of …, 2019 - mdpi.com
Vascular risk factors, such as type 2 diabetes mellitus (T2DM), are associated with the
increased risk of Alzheimer's disease. One of the common T2DM medications, dipeptidyl …
increased risk of Alzheimer's disease. One of the common T2DM medications, dipeptidyl …
Neuroprotective properties of linagliptin: focus on biochemical mechanisms in cerebral ischemia, vascular dysfunction and certain neurodegenerative diseases
M Wiciński, K Górski, M Walczak, E Wódkiewicz… - International Journal of …, 2019 - mdpi.com
Linagliptin is a representative of dipeptidyl peptidase 4 (DPP-4) inhibitors which are
registered and used effectively in a treatment of diabetes mellitus type 2. They increase the …
registered and used effectively in a treatment of diabetes mellitus type 2. They increase the …
Vascular protection of DPP-4 inhibitors in retinal endothelial cells in in vitro culture
H Li, J Zhang, L Lin, L Xu - International Immunopharmacology, 2019 - Elsevier
People with diabetes are at high risk of developing diabetes-related eye disease, termed as
diabetic retinopathy, due damage being caused to the blood vessels in the retina. An …
diabetic retinopathy, due damage being caused to the blood vessels in the retina. An …
Linagliptin prevents left ventricular stiffening by reducing titin cleavage and hypophosphorylation
I Cuijpers, AP Papageorgiou, P Carai… - Journal of Cellular …, 2021 - Wiley Online Library
The metabolic syndrome (MetS) is an escalating problem worldwide, causing left ventricular
stiffening, an early characteristic of diastolic dysfunction for which no treatment exists. As …
stiffening, an early characteristic of diastolic dysfunction for which no treatment exists. As …
Maternal high-fat diet programs cerebrovascular remodeling in adult rat offspring
CC Lin, XY Wu, YL Zhou, B Shao… - Journal of Cerebral …, 2018 - journals.sagepub.com
Maternal environmental factors such as diet have consequences on later health of the
offspring. We found that maternal high-fat diet (HFD) exposure renders adult offspring brain …
offspring. We found that maternal high-fat diet (HFD) exposure renders adult offspring brain …
A review of variable risk factors affecting the development of mild cognitive impairment in older adults
C Zhang, H Fan, M Li - Aging Pathobiology and Therapeutics, 2023 - antpublisher.com
Mild cognitive impairment (MCI) is considered to be a transitional state in which cognitive
function gradually deteriorates from normal to dementia, which is mainly characterized by …
function gradually deteriorates from normal to dementia, which is mainly characterized by …