[HTML][HTML] Clopidogrel therapy and CYP2C19 genotype

L Dean, M Kane - 2018 - europepmc.org
Clopidogrel (brand name Plavix) is an antiplatelet medicine that reduces the risk of
myocardial infarction (MI) and stroke in individuals with acute coronary syndrome (ACS) …

Contemporary antiplatelet therapy for secondary stroke prevention: a narrative review of current literature and guidelines

J Shah, S Liu, W Yu - Stroke and vascular neurology, 2022 - svn.bmj.com
Antiplatelet therapy is one of the mainstays for secondary stroke prevention. This narrative
review aimed to highlight the current evidence and recommendations of antiplatelet therapy …

Effect of antiplatelet therapy on the incidence, prognosis, and rebleeding of intracerebral hemorrhage

Y Li, X Liu, S Chen, J Wang, C Pan… - CNS Neuroscience & …, 2023 - Wiley Online Library
Objective Antiplatelet medications are increasingly being used for primary and secondary
prevention of ischemic attacks owing to the increasing prevalence of ischemic stroke …

Pharmacogenetics of P2Y12 receptor inhibitors

CD Thomas, AK Williams, CR Lee… - … : The Journal of …, 2023 - Wiley Online Library
Oral P2Y12 inhibitors are commonly prescribed for cardiovascular disease and include
clopidogrel, prasugrel, and ticagrelor. Each of these drugs has its strengths and …

Monitoring antiplatelet therapy: where are we now?

R Marcucci, M Berteotti, F Gragnano… - Journal of …, 2023 - journals.lww.com
Single antiplatelet therapy represents the cornerstone of thrombosis prevention in
atherosclerotic cardiovascular disease. Dual antiplatelet therapy (DAPT), consisting of …

Antiplatelet resistance: a review of concepts, mechanisms, and implications for management in acute ischemic stroke and transient ischemic attack

K Krishnan, TN Nguyen, JP Appleton… - Stroke: Vascular and …, 2023 - Am Heart Assoc
Acute ischemic stroke is a leading cause of death and major disability worldwide.
Approximately 50% of ischemic strokes are caused by atherothrombotic occlusion of the …

Roundtable of Academia and Industry for Stroke Prevention: Prevention and Treatment of Large-Vessel Disease

S Yaghi, C Albin, S Chaturvedi, SI Savitz - Stroke, 2024 - Am Heart Assoc
The Roundtable of Academia and Industry for Stroke Prevention conference convened a
panel to discuss important topics to advance the treatment and prevention of large-vessel …

The implementation of pharmacogenetics in the United Kingdom

JH McDermott, V Sharma, J Keen, WG Newman… - Precision Medicine, 2023 - Springer
There is considerable inter-individual variability in the effectiveness and safety of
pharmaceutical interventions. This phenomenon can be attributed to a multitude of factors; …

Residual Risk of Trimethylamine‐N‐Oxide and Choline for Stroke Recurrence in Patients With Intensive Secondary Therapy

J Xue, J Xu, M Zhao, A Jin, A Cheng… - Journal of the …, 2022 - Am Heart Assoc
Background Trimethylamine N‐oxide (TMAO) contributes to cardiovascular disease through
its prothrombotic, proatherothrombotic, and proinflammatory effects. We aimed to evaluate …

[HTML][HTML] The impact of triglyceride-glucose index on ischemic stroke: a systematic review and meta-analysis

Y Yang, X Huang, Y Wang, L Leng, J Xu, L Feng… - Cardiovascular …, 2023 - Springer
Background Strokes significantly impair quality of life and incur high economic and societal
burdens. The triglyceride and glucose (TyG) index is a biochemical marker of insulin …