Kidney tubular epithelial cells (TECs) have a crucial role in the damage and repair response
to acute and chronic injury. To adequately respond to constant changes in the environment …

Neuronal loss is one of the striking causes of various central nervous system disorders,
including major neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's …

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS)
associated with inappropriate activation of lymphocytes, hyperinflammatory responses …

Mitochondrial dysfunction is the most prominent source of oxidative stress in acute and
chronic kidney disease. NLRX1 is a receptor of the innate immune system that is …

Neuronal disorders are associated with a profound loss of mitochondrial functions caused
by various stress conditions, such as oxidative and metabolic stress, protein folding or import …

Nucleotide-binding oligomerization domain-like receptors (NLRs), including NLRAs, NLRBs
(also known as NAIPs), NLRCs, and NLRPs, are a major subfamily of pattern recognition …

NLRX1 is a member of the of the Nod-like receptor (NLR) family, and it represents a unique
pattern recognition molecule (PRM) as it localizes to the mitochondrial matrix in resting …

Increasing evidence suggests that inflammation and apoptosis are involved in the
development of acute myocardial ischemia (AMI). Nucleotide-binding oligomerization …

Traumatic and nontraumatic brain injury results from severe disruptions in the cellular
microenvironment leading to massive loss of neuronal populations and increased …

Intervertebral disc degeneration (IDD) is the most critical pathological factor in the
development of low back pain. The maintenance of nucleus pulposus (NP) cell and …