Advances in TRP channel drug discovery: from target validation to clinical studies
AP Koivisto, MG Belvisi, R Gaudet… - Nature reviews Drug …, 2022 - nature.com
Transient receptor potential (TRP) channels are multifunctional signalling molecules with
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …
[HTML][HTML] Mammalian transient receptor potential TRPA1 channels: from structure to disease
K Talavera, JB Startek, J Alvarez-Collazo… - Physiological …, 2020 - journals.physiology.org
The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …
cation channels remarkably conserved through the animal kingdom. Mammals have only …
The Utility of Capsicum annuum L. in Internal Medicine and In Dentistry: A Comprehensive Review
LM Catalfamo, G Marrone, M Basilicata… - International Journal of …, 2022 - mdpi.com
Capsaicin is a chili peppers extract, genus Capsicum, commonly used as a food spice.
Since ancient times, Capsaicin has been used as a “homeopathic remedy” for treating a wild …
Since ancient times, Capsaicin has been used as a “homeopathic remedy” for treating a wild …
Mechanisms of acute and chronic pain after surgery: update from findings in experimental animal models
E Pogatzki-Zahn, D Segelcke… - Current Opinion in …, 2018 - journals.lww.com
Mechanisms of acute and chronic pain after surgery: update f... : Current Opinion in
Anesthesiology Mechanisms of acute and chronic pain after surgery: update from findings in …
Anesthesiology Mechanisms of acute and chronic pain after surgery: update from findings in …
Acute and chronic pain from facial skin and oral mucosa: unique neurobiology and challenging treatment
The oral cavity is a portal into the digestive system, which exhibits unique sensory
properties. Like facial skin, the oral mucosa needs to be exquisitely sensitive and selective …
properties. Like facial skin, the oral mucosa needs to be exquisitely sensitive and selective …
The mechanisms and management of persistent postsurgical pain
AM Fuller, S Bharde, S Sikandar - Frontiers in Pain Research, 2023 - frontiersin.org
An estimated 10%–50% of patients undergoing a surgical intervention will develop
persistent postsurgical pain (PPP) lasting more than 3 months despite adequate acute pain …
persistent postsurgical pain (PPP) lasting more than 3 months despite adequate acute pain …
NLRP3 inflammasomes are involved in the progression of postoperative cognitive dysfunction: from mechanism to treatment
S Zhao, F Chen, D Wang, W Han, Y Zhang, Q Yin - Neurosurgical review, 2021 - Springer
Postoperative cognitive dysfunction (POCD) involves patient memory and learning decline
after surgery. POCD not only presents challenges for postoperative nursing and recovery but …
after surgery. POCD not only presents challenges for postoperative nursing and recovery but …
Progress in animal models of trigeminal neuralgia
X Ma, T Zhu, J Ke - Archives of oral biology, 2023 - Elsevier
Objective This review aims to systematically summarize the methods of establishing various
models of trigeminal neuralgia (TN), the scope of application, and current animals used in …
models of trigeminal neuralgia (TN), the scope of application, and current animals used in …
Acute orofacial pain leads to prolonged changes in behavioral and affective pain components
EI Araya, DF Baggio, L de Oliveira Koren, R Andreatini… - Pain, 2020 - journals.lww.com
Acute pain that persists for a few days is associated with a reduction in patients' quality of
life. Orofacial persistent pain promotes psychological disorders such as anxiety, impairs …
life. Orofacial persistent pain promotes psychological disorders such as anxiety, impairs …
Oxytocin-dependent regulation of TRPs expression in trigeminal ganglion neurons attenuates orofacial neuropathic pain following infraorbital nerve injury in rats
M Ando, Y Hayashi, S Hitomi, I Shibuta… - International journal of …, 2020 - mdpi.com
We evaluated the mechanisms underlying the oxytocin (OXT)-induced analgesic effect on
orofacial neuropathic pain following infraorbital nerve injury (IONI). IONI was established …
orofacial neuropathic pain following infraorbital nerve injury (IONI). IONI was established …