Transforming growth factor-β (TGF)-β signaling plays a crucial role in the development and
maintenance of various organs, including the vasculature. Accordingly, the mutations in TGF …

Thoracic aortic aneurysms that progress to acute aortic dissections are often fatal. Thoracic
aneurysms have been managed with treatment with β-adrenergic blocking agents (β …

Thoracic aortic aneurysm, as occurs in Marfan syndrome, is generally asymptomatic until
dissection or rupture, requiring surgical intervention as the only available treatment. Here …

Marfan syndrome (MFS) is an autosomal dominant, age-related but highly penetrant
condition with substantial intrafamilial and interfamilial variability. MFS is caused by …

Loeys-Dietz syndrome is an autosomal dominant aortic aneurysm syndrome characterized
by multisystemic involvement. The most typical clinical triad includes hypertelorism, bifid …

About 20% of individuals afflicted with thoracic aortic disease have single-gene mutations
that predispose the vessel to aneurysm formation and/or acute aortic dissection often without …

Patients with Marfan syndrome (MFS) develop thoracic aortic aneurysms as the aorta
presents excessive elastin breaks, fibrosis, and vascular smooth muscle cell (vSMC) death …

Recent studies have shown that NO is a central mediator in diseases associated with
thoracic aortic aneurysm, such as Marfan syndrome. The progressive dilation of the aorta in …

Background Thoracic aortic aneurysm and aortic dissection (TAAD) is one of the most fatal
cardiovascular diseases. Senkyunolide I (SEI) is a component of traditional Chinese …

Objective The prevalence of Marfan syndrome (MFS) is estimated to be 1 in 10,000 to
15,000 individuals, but the phenotype of MFS may not be apparent and hence its diagnosis …