Charge detection mass spectrometry (CDMS) is a single-particle technique where the
masses of individual ions are determined from simultaneous measurement of their mass-to …

The pathogenic bacterium Streptococcus pneumoniae (S. pneumoniae) can invade the
cerebrospinal fluid (CSF) and cause meningitis with devastating consequences. Whether …

Viruses have evolved to exploit the vast complexity of cellular processes for their success
within the host cell. The entry mechanisms of enveloped viruses (viruses with a surrounding …

Alphaviruses represent a diverse set of arboviruses, many of which are important
pathogens. Chikungunya virus (CHIKV), an arthritis-inducing alphavirus, is the cause of a …

It is widely held that arboviruses such as the alphavirus Sindbis virus gain entry into cells by
a process of receptor-mediated endocytosis followed by membrane fusion in the acid …

Sindbis virus (SINV) is an enveloped, single-stranded RNA virus, which is transmitted via
mosquitos to a wide range of vertebrate hosts. SINV produced by vertebrate, baby hamster …

Members of the Alphavirus genus are arboviruses that alternate replication in mosquitoes
and vertebrate hosts. In vertebrate cells, the alphavirus resists the activation of antiviral RNA …

Single particle cryo-electron microscopy (cryo-EM) is an emerging powerful tool for structural
studies of macromolecular assemblies (ie, protein complexes and viruses). Although single …

Cholesterol has been shown to be essential for the fusion of alphaviruses with artificial
membranes (liposomes). Cholesterol has also been implicated as playing an essential and …

Pathogenesis and reservoir host adaptation of animal and zoonotic viruses are poorly
understood due to missing adequate cell culture and animal models. The bank vole …