[HTML][HTML] The influence of evolutionary history on human health and disease
Nearly all genetic variants that influence disease risk have human-specific origins; however,
the systems they influence have ancient roots that often trace back to evolutionary events …
the systems they influence have ancient roots that often trace back to evolutionary events …
The p53 network: cellular and systemic DNA damage responses in cancer and aging
PL Vaddavalli, B Schumacher - Trends in Genetics, 2022 - cell.com
The tumor protein TP53 gene, encoding the cellular tumor antigen p53, is the single most
frequently mutated gene in human cancers. p53 plays a central role in responding to DNA …
frequently mutated gene in human cancers. p53 plays a central role in responding to DNA …
Putting p53 in context
ER Kastenhuber, SW Lowe - Cell, 2017 - cell.com
TP53 is the most frequently mutated gene in human cancer. Functionally, p53 is activated by
a host of stress stimuli and, in turn, governs an exquisitely complex anti-proliferative …
a host of stress stimuli and, in turn, governs an exquisitely complex anti-proliferative …
Mechanisms of cancer resistance in long-lived mammals
A Seluanov, VN Gladyshev, J Vijg… - Nature Reviews Cancer, 2018 - nature.com
Cancer researchers have traditionally used the mouse and the rat as staple model
organisms. These animals are very short-lived, reproduce rapidly and are highly prone to …
organisms. These animals are very short-lived, reproduce rapidly and are highly prone to …
Gain-of-function mutant p53: all the roads lead to tumorigenesis
Y Stein, V Rotter, R Aloni-Grinstein - International journal of molecular …, 2019 - mdpi.com
The p53 protein is mutated in about 50% of human cancers. Aside from losing the tumor-
suppressive functions of the wild-type form, mutant p53 proteins often acquire inherent …
suppressive functions of the wild-type form, mutant p53 proteins often acquire inherent …
The genetics of aging: a vertebrate perspective
Aging negatively impacts vitality and health. Many genetic pathways that regulate aging
were discovered in invertebrates. However, the genetics of aging is more complex in …
were discovered in invertebrates. However, the genetics of aging is more complex in …
The consequences of chromosome segregation errors in mitosis and meiosis
T Potapova, GJ Gorbsky - Biology, 2017 - mdpi.com
Mistakes during cell division frequently generate changes in chromosome content,
producing aneuploid or polyploid progeny cells. Polyploid cells may then undergo abnormal …
producing aneuploid or polyploid progeny cells. Polyploid cells may then undergo abnormal …
Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation
Mammals differ more than 100-fold in maximum lifespan. Here, we conducted comparative
transcriptomics on 26 species with diverse lifespans. We identified thousands of genes with …
transcriptomics on 26 species with diverse lifespans. We identified thousands of genes with …
Alternative animal models of aging research
S Holtze, E Gorshkova, S Braude… - Frontiers in Molecular …, 2021 - frontiersin.org
Most research on mechanisms of aging is being conducted in a very limited number of
classical model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus …
classical model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus …
The landscape of gene mutations in cirrhosis and hepatocellular carcinoma
M Müller, TG Bird, JC Nault - Journal of hepatology, 2020 - Elsevier
Chronic liver disease and primary liver cancer are a massive global problem, with a future
increase in incidences predicted. The most prevalent form of primary liver cancer …
increase in incidences predicted. The most prevalent form of primary liver cancer …