Objective: To attempt to determine the relative value of preclinical cardiac electrophysiology
data (in vitro and in vivo) for predicting risk of torsade de pointes (TdP) in clinical use …

Assessment of proarrhythmic toxicity of newly developed drugs attracts significant attention
from drug developers and regulatory agencies. Although no guidelines exist for such …

QT interval prolongation is so frequently associated with torsades de pointes (TdP) that it
has come to be recognized as a surrogate marker of this unique tachyarrhythmia. However …

Ranolazine is a novel antianginal agent capable of producing anti-ischemic effects at
plasma concentrations of 2 to 6 μM without a significant reduction of heart rate or blood …

The past 5 years has witnessed an advance in our understanding of alpha1G (Ca v 3.1),
alpha1H (Ca v 3.2), and alpha1l (Ca v 3.3), the pore-forming subunits of T-type or low …

Key points Lymph transport is promoted by lymphatic pumping, a robust phasic contractile
activity of the collecting lymphatic vessels. This contractile function, critical for tissue fluid …

Introduction The use of multi-electrode arrays (MEA) in combination with human induced
pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provides a promising method to …

With the aim of reconsidering ICH S7B and E14 guidelines, a new in vitro assay system has
been subjected to worldwide validation to establish a better prediction platform for potential …

Mutations in the Ca V 1.2 L-type calcium channel can cause a profound form of long-QT
syndrome known as long-QT type 8 (LQT8), which results in cardiac arrhythmias that are …

Background: The electrocardiographic QT interval is used to identify drugs with potential
harmful effects on cardiac repolarization in drug trials, but the variability of the measurement …