Introduction: Preclinical evaluation of delayed ventricular repolarization manifests
electrocardiographically as QT interval prolongation and is routinely used as an indicator of …

The goal of this study was to analyze the effects of mibefradil on a human cardiac K+
channel (hKv1. 5) stably expressed in Chinese hamster ovary cells using the whole-cell …

This study adds the dimension of a T‐wave morphology composite score (MCS) to the QTc
interval–based evaluation of drugs that affect cardiac repolarization. Electrocardiographic …

Both L-and T-type calcium channels are present in the heart. In cardiac myocytes L-type
calcium channels are blocked by the classical calcium channel blockers, while T-type …

The pro-arrhythmic risk inherent to a new drug must be assessed at an early preclinical
stage. Telemetry system implantation is a method widely used in vivo in various species …

Cardiac arrhythmias are a major cause of morbidity and mortality in the industrialized world.
Among their treatment regimens one can find the calcium channel antagonists (CCAs), the …

Introduction: This project addresses the validation study design of a test system using a
telemetered non-human primate model for cardiovascular safety pharmacology evaluation …

Expression and function of cardiac ion channels exhibit postnatal developmental changes,
which, however, has not yet been proven in ventricular myocytes isolated using similar …

During the last ICH Expert Working Group meeting for Safety Pharmacology in February
2002 in Brussels, the appended step 2 S7B document on QT Prolongation was signed off …

Tapentadol is a novel analgesic with µ‐opioid receptor agonistic and norepinephrine
reuptake inhibiting activities at submicromolar concentrations. Given that inhibition of …