Mesenchymal stem cells (MSCs) have been widely studied as a versatile cell source for
tissue regeneration and remodeling due to their potent bioactivity, which includes …

As the adult mammalian heart has limited potential for regeneration and repair, the loss of
cardiomyocytes during injury and disease can result in heart failure and death. The cellular …

The effectiveness of stem cell therapies has been hampered by cell death and limited
control over fate. These problems can be partially circumvented by using macroporous …

Myocardial infarction is a leading cause of death among all cardiovascular diseases. The
analysis of molecular mechanisms by which the ischemic myocardium initiates repair and …

The broad repertoire of secreted trophic and immunomodulatory cytokines produced by
mesenchymal stem cells (MSCs), generally referred to as the MSC secretome, has …

Importance Stem cell therapy is a promising treatment strategy for patients with heart failure,
which accounts for more than 10% of deaths in the United States annually. Despite more …

Microvesicles represent a newly identified mechanism of intercellular communication. Two
different types of microvesicles have been identified: membrane-derived vesicles (EVs) and …

Objectives: This study sought to evaluate the feasibility and safety of autologous bone
marrow–derived and cardiogenically oriented mesenchymal stem cell therapy and to probe …

Cardiovascular disease is a major target for many experimental stem cell-based therapies
and mesenchymal stem cells (MSCs) are widely used in these therapies. Transplantation of …

Extracellular vesicles (EV s), membrane vesicles that are secreted by a variety of
mammalian cell types, have been shown to play an important role in intercellular …