Overview of the 2022 WHO classification of neuroendocrine neoplasms

G Rindi, O Mete, S Uccella, O Basturk, S La Rosa… - Endocrine …, 2022 - Springer
In this review, we detail the changes and the relevant features that are applied to
neuroendocrine neoplasms (NENs) in the 2022 WHO Classification of Endocrine and …

[HTML][HTML] Lung neuroendocrine neoplasms: recent progress and persistent challenges

N Rekhtman - Modern Pathology, 2022 - Elsevier
This review summarizes key recent developments relevant to the pathologic diagnosis of
lung neuroendocrine neoplasms, including carcinoids, small cell lung carcinoma (SCLC) …

[HTML][HTML] INSM1, a novel biomarker for detection of neuroendocrine neoplasms: cytopathologists' view

Z Maleki, A Nadella, M Nadella, G Patel, S Patel… - Diagnostics, 2021 - mdpi.com
Background: Insulinoma-associated protein 1 (INSM1) has been considered as a novel
immunostain for neuroendocrine tumors (NETs) and is hypothesized to be more reliable …

The complex histopathological and immunohistochemical spectrum of neuroendocrine tumors—an overview of the latest classifications

AA Gheorghișan-Gălățeanu, A Ilieșiu… - International Journal of …, 2023 - mdpi.com
Neuroendocrine neoplasms (NENs) originate from the neuroendocrine cell system, which
may either take the shape of organoid cell aggregations or be composed of dispersed cells …

Insulinoma-associated-1 (INSM1) expression in thymic squamous cell carcinoma

J Kashima, T Hashimoto, A Yoshida, Y Goto, T Ushiku… - Virchows Archiv, 2022 - Springer
Thymic squamous cell carcinoma (TSC) presents distinct immunohistochemical features
with its expression of CD5 and CD117, both of which are rarely expressed in squamous cell …

[HTML][HTML] Comparison of INSM1 immunostaining with established neuroendocrine markers synaptophysin and chromogranin A in over 14,000 neuroendocrine and non …

K Möller, R Uhlig, N Gorbokon, D Dum, A Menz… - Molecular and Cellular …, 2024 - Elsevier
INSM1 is a transcription factor protein which is increasingly used as an
immunohistochemical marker for neuroendocrine differentiation. To determine the …

From the ashes of “Ewing-like” sarcoma: A contemporary update of the classification, immunohistochemistry, and molecular genetics of round cell sarcomas

ME Kallen, JL Hornick - Seminars in Diagnostic Pathology, 2022 - Elsevier
Round cell sarcomas include a diverse group of bone and soft tissue tumors, which
comprise well-defined entities as well as several nascent categories presented in the 2020 …

Thoracic nuclear protein in testis (NUT) carcinoma: expanded pathological spectrum with expression of thyroid transcription factor‐1 and neuroendocrine markers

YP Hung, AL Chen, MS Taylor, TG Huynh… - …, 2021 - Wiley Online Library
Aims Nuclear protein in testis (NUT) carcinoma, an aggressive tumour driven by NUTM1
rearrangements, often involves the lung/mediastinum and shows squamous differentiation …

INSM1 is less sensitive but more specific than synaptophysin in gynecologic high-grade neuroendocrine carcinomas: an immunohistochemical study of 75 cases with …

Q Zou, L Zhang, Z Cheng, X Guo… - The American Journal of …, 2021 - journals.lww.com
Abstract Insulinoma-associated protein 1 (INSM1) has emerged as a promising diagnostic
marker for high-grade neuroendocrine carcinomas (HGNECs); however, it is controversial …

Treatment-related neuroendocrine prostate carcinoma—diagnostic and molecular correlates

A Gopalan - Advances in Anatomic Pathology, 2024 - journals.lww.com
Abstract Treatment-related neuroendocrine prostate cancer is a distinctive category of
prostate cancer that arises after intensive suppression of the androgen receptor by next …