MicroRNAs (miRNAs) are a class of small, well-conserved noncoding RNAs that regulate
gene expression post-transcriptionally. They have been demonstrated to regulate a lot of …

Copy number variants (CNVs) play an important role in human disease and population
diversity. Advancements in technology have allowed for the analysis of CNVs in thousands …

Tetralogy of Fallot (TOF), the most common severe congenital heart malformation, occurs
sporadically, without other anomaly, and from unknown cause in 70% of cases. Through a …

While it is known that rare copy-number variants (CNVs) contribute to risk for some
neuropsychiatric disorders, the role of CNVs in bipolar disorder is unclear. Here, we …

Schizophrenia likely results from poorly understood genetic and environmental factors. We
studied the gene encoding the synaptic protein SHANK3 in 285 controls and 185 …

Context Results of comparative genomic hybridization studies have suggested that rare
copy number variations (CNVs) at numerous loci are involved in the cause of mental …

Objective: The authors conducted a review of the history and empirical basis of genomewide
association studies (GWAS), the rationale for GWAS of psychiatric disorders, results to date …

Psychiatric disorders such as schizophrenia, bipolar disorder, major depressive disorder,
attention-deficit/hyperactivity disorder and autism spectrum disorder are common and result …

Deletions within the neurexin 1 gene (NRXN1; 2p16. 3) are associated with autism and have
also been reported in two families with schizophrenia. We examined NRXN1, and the …

There is strong evidence that genetic factors make substantial contributions to the etiology of
autism, schizophrenia and bipolar disorders, with heritability estimates being at least 80 …