In silico modelling of cancer nanomedicine, across scales and transport barriers
Nanoparticles promise to improve the treatment of cancer through their increasingly
sophisticated functionalisations and ability to accumulate in certain tumours. Yet recent work …
sophisticated functionalisations and ability to accumulate in certain tumours. Yet recent work …
Closed-loop control of anesthesia: Survey on actual trends, challenges and perspectives
Automation empowers self-sustainable adaptive processes and personalized services in
many industries. The implementation of the integrated healthcare paradigm built on Health …
many industries. The implementation of the integrated healthcare paradigm built on Health …
[HTML][HTML] In silico trials: Verification, validation and uncertainty quantification of predictive models used in the regulatory evaluation of biomedical products
Historically, the evidences of safety and efficacy that companies provide to regulatory
agencies as support to the request for marketing authorization of a new medical product …
agencies as support to the request for marketing authorization of a new medical product …
Consideration of a credibility assessment framework in model‐informed drug development: potential application to physiologically‐based pharmacokinetic modeling …
C Kuemmel, Y Yang, X Zhang, J Florian… - CPT …, 2020 - Wiley Online Library
The use of computational models in drug development has grown during the past decade.
These model‐informed drug development (MIDD) approaches can inform a variety of drug …
These model‐informed drug development (MIDD) approaches can inform a variety of drug …
Credibility assessment of in silico clinical trials for medical devices
In silico clinical trials (ISCTs) are an emerging method in modeling and simulation where
medical interventions are evaluated using computational models of patients. ISCTs have the …
medical interventions are evaluated using computational models of patients. ISCTs have the …
Physiological closed-loop control (PCLC) systems: Review of a modern frontier in automation
Over the past decade, there has been an unprecedented international focus on improved
quality and availability of medical care, which has reignited interest in clinical automation …
quality and availability of medical care, which has reignited interest in clinical automation …
Use of computational modeling to study joint degeneration: a review
S Mukherjee, M Nazemi, I Jonkers… - … in Bioengineering and …, 2020 - frontiersin.org
Osteoarthritis (OA), a degenerative joint disease, is the most common chronic condition of
the joints, which cannot be prevented effectively. Computational modeling of joint …
the joints, which cannot be prevented effectively. Computational modeling of joint …
Peri‐operative considerations for sedation‐analgesia during cataract surgery: a narrative review
Cataract surgery is usually of short duration and is associated with minimal pain when
employing topical or regional anaesthesia. Patient education regarding the peri‐operative …
employing topical or regional anaesthesia. Patient education regarding the peri‐operative …
Design and execution of a verification, validation, and uncertainty quantification plan for a numerical model of left ventricular flow after LVAD implantation
Background Left ventricular assist devices (LVADs) are implantable pumps that act as a life
support therapy for patients with severe heart failure. Despite improving the survival rate …
support therapy for patients with severe heart failure. Despite improving the survival rate …
Physiological closed-loop control in critical care: opportunities for innovations
Physiological closed-loop control (PCLC) systems are a key enabler for automation and
clinician support in medicine, including, but not limited to, patient monitoring, diagnosis …
clinician support in medicine, including, but not limited to, patient monitoring, diagnosis …