Clinical efficacy and safety of lacosamide as an adjunctive treatment in adults with refractory epilepsy

L Hou, B Peng, D Zhang, J Yang, Y Wang… - Frontiers in …, 2021 - frontiersin.org
Background: Lacosamide (LCM), a novel AED (antiepileptic drug), was used as an
adjunctive treatment in patients with partial-onset seizures or without secondary …

The impact of lacosamide on mood disorders in adult patients with epilepsy: a systematic review

S Toniolo, F Di Lorenzo, M Bozzali, M Yogarajah - Epilepsy & Behavior, 2020 - Elsevier
Mood disorders such as depression and anxiety have a high prevalence in adult patients
with epilepsy, and their evaluation is crucial in choosing the most appropriate antiepileptic …

Real-world analysis of retention on cenobamate in patients with epilepsy in the United States

S Stern, M Weingarten, S Mandapati, L Ferrari… - Epilepsy Research, 2023 - Elsevier
Background This retrospective, observational study used US claims data to assess retention
rates on cenobamate compared with four branded antiseizure medications (ASMs) in …

Use of real‐world data and pharmacometric modeling in support of lacosamide dosing in pediatric patients under 4 years of age

PB Lukka, M Woods, R Chhim… - The Journal of …, 2021 - Wiley Online Library
The antiepileptic drug lacosamide (LCM) is approved in the United States and the European
Union as monotherapy as well as adjunctive therapy for the treatment of focal seizures in …

Efficacy and tolerability of immediate switch from sodium channel blockers to Lacosamide

OT Özgün, MK Yılmaz, MM Atmaca, SK Güler… - Epilepsy & Behavior, 2023 - Elsevier
Lacosamide (LCM) is a new-generation anti-seizure medication approved for monotherapy
and add-on therapy for focal-onset epilepsy. It has novel pharmacodynamics and favorable …

[HTML][HTML] The retention of lacosamide in patients with epilepsy and intellectual disability in three specialised institutions

J Brenner, HJM Majoie, S van Beek, JA Carpay - Seizure, 2017 - Elsevier
Purpose We describe the effectiveness of lacosamide as adjunctive therapy in patients with
epilepsy and an intellectual disability. This information is relevant, as few data exist …

[HTML][HTML] The effect of lacosamide on psychiatric comorbidities in patients with epilepsy

N Hasegawa, M Fukuda - Epilepsy & Behavior Reports, 2020 - Elsevier
We investigated the efficacy of lacosamide (LCM) polytherapy in improving seizure
outcomes and psychiatric symptoms in patients with epilepsy with psychiatric comorbidities …

Investigation of the efficacy and adverse effects of lacosamide over 36 months

K Wakabayashi, H Osaka, H Yamagishi, M Kuwajima… - Epilepsy & Behavior, 2023 - Elsevier
Objective To evaluate the efficacy and retention rate of lacosamide (LCM) over 36 months as
a treatment for children and adolescents with focal and generalized epilepsy based on a …

[HTML][HTML] Lacosamide-induced excessive laughing in a patient with Lennox–Gastaut syndrome

H Algahtani, B Shirah, R Algahtani - Epilepsy & Behavior Case Reports, 2018 - Elsevier
Lacosamide is one of the third-generation antiseizure drugs that block voltage-gated sodium
channels by enhancing slow inactivation. The most common adverse effects of lacosamide …

Clinical experience combined with therapeutic drug monitoring of lacosamide

T Svendsen, E Brodtkorb, A Baftiu… - Acta Neurologica …, 2020 - Wiley Online Library
Objective Lacosamide (LCM) is an antiepileptic drug (AED) with insufficient clinical
experience in patients with intellectual disability (ID). They often have more severe epilepsy …