BACKGROUND: Outpatient care accounts for a significant proportion of total heart failure
(HF) expenditures. This observation, plus an expanding list of treatment options, has led to …

Randomized experiments are the “gold standard” for estimating causal effects, yet often in
practice, chance imbalances exist in covariate distributions between treatment groups. If …

When conducting a randomized experiment, if an allocation yields treatment groups that
differ meaningfully with respect to relevant covariates, groups should be rerandomized. The …

Medications are the second largest and fastest growing health care cost in Canada. 1 In
2010, there were 499.6 million prescriptions dispensed across Canada, representing a total …

Randomization ensures that observed and unobserved covariates are balanced, on
average. However, randomizing units to treatment and control often leads to covariate …

Introduction: Knowledge translation (KT) initiatives have the potential to improve prescribing
quality and produce savings that exceed the cost of the KT program itself, including the cost …

Rerandomization discards assignments with covariates unbalanced in the treatment and
control groups to improve estimation and inference efficiency. However, the acceptance …

Background Exposure to opioid analgesics have historically raised concern for a risk of
developing opioid use disorder. Prescriber audit-and-feedback interventions may reduce …

Background: Centralized administrative databases enable low-cost pragmatic randomized
trials (PRTs) of drug effectiveness and safety. We simplified the PRT strategy by using …

Randomized experiments are the" gold standard" for conducting research and establishing
a causal effect, yet often in practice chance imbalances exist in covariates. If covariate data …