Bruton's tyrosine kinase (BTK) is an essential component of multiple signaling pathways that
regulate B cell and myeloid cell proliferation, survival, and functions, making it a promising …

MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

Non-Hodgkin lymphomas (NHL) are lymphoid tumors that arise by a complex process of
malignant transformation of mature lymphocytes during various stages of differentiation. The …

Fluorine is characterized by high electronegativity and small atomic size, which provide this
molecule with the unique property of augmenting the potency, selectivity, metabolic stability …

T-lymphocytes are prevalent in the tumor microenvironment of follicular lymphoma (FL).
However, the phenotype of T-cells may vary, and the prevalence of certain T-cell subsets …

Abstract B-cell lymphoma 6 (BCL6) is a protooncogene in adult and pediatric cancers, first
identified in diffuse large B-cell lymphoma (DLBCL) where it acts as a repressor of the tumor …

Axicabtagene ciloleucel (axi-cel) is an autologous anti-CD19 chimeric antigen receptor
(CAR) T-cell therapy approved for relapsed/refractory (R/R) follicular lymphoma (FL) …

Simple Summary Immune-based treatment strategies, which include immune checkpoint
inhibition, have recently become a new frontier for the treatment of B-cell-derived lymphoma …

Abstract Phosphatidylinositol 3-kinases (PI3Ks) are a family of intracellular signal transducer
enzymes that can attach a phosphate group to the 3'-hydroxyl of the inositol moiety of …

Interleukin (IL)-22 is a potent mediator of inflammatory responses. The IL-22 receptor
consists of the IL-22Rα and IL-10Rβ subunits. Previous studies have shown that IL-22Rα …