[HTML][HTML] Stromal cells in the tumor microenvironment: accomplices of tumor progression?

Y Zhao, M Shen, L Wu, H Yang, Y Yao, Q Yang… - Cell Death & …, 2023 - nature.com
The tumor microenvironment (TME) is made up of cells and extracellular matrix (non-cellular
component), and cellular components include cancer cells and non-malignant cells such as …

[HTML][HTML] Apoptotic bodies: bioactive treasure left behind by the dying cells with robust diagnostic and therapeutic application potentials

L Yu, G Zhu, Z Zhang, Y Yu, L Zeng, Z Xu… - Journal of …, 2023 - Springer
Apoptosis, a form of programmed cell death, is essential for growth and tissue homeostasis.
Apoptotic bodies (ApoBDs) are a form of extracellular vesicles (EVs) released by dying cells …

Quantitative Comparison of Gold Nanoparticle Delivery via the Enhanced Permeation and Retention (EPR) Effect and Mesenchymal Stem Cell (MSC)-Based …

L Xu, M Xu, X Sun, N Feliu, L Feng, WJ Parak, S Liu - ACS nano, 2023 - ACS Publications
There are still some gaps in existing knowledge in the field of cancer nanotheranostics, eg.,
the efficiency of nanoparticle-loaded cells for targeted delivery. In the current study, gold …

Carcinoma-associated mesenchymal stem/stromal cells: architects of the pro-tumorigenic tumor microenvironment

L Frisbie, RJ Buckanovich, L Coffman - Stem Cells, 2022 - academic.oup.com
The interaction between tumor cells and non-malignant hosts cells within the tumor
microenvironment (TME) is critical to the pathophysiology of cancer. These non-malignant …

[HTML][HTML] Mesenchymal stromal cells plus basiliximab, calcineurin inhibitor as treatment of steroid-resistant acute graft-versus-host disease: a multicenter, randomized …

K Zhao, R Lin, Z Fan, X Chen, Y Wang, F Huang… - Journal of hematology & …, 2022 - Springer
Background Steroid-resistant (SR) acute graft-versus-host disease (aGVHD) lacks standard
second-line treatment. Mesenchymal stromal cells (MSCs) have potential efficacy in SR …

[HTML][HTML] Cancer resistance to immunotherapy: comprehensive insights with future perspectives

SS Said, WN Ibrahim - Pharmaceutics, 2023 - mdpi.com
Cancer immunotherapy is a type of treatment that harnesses the power of the immune
systems of patients to target cancer cells with better precision compared to traditional …

Nanoghosts: harnessing mesenchymal stem cell membrane for construction of Drug Delivery platforms Via Optimized Biomimetics

Y Xiao, RH Xu, Y Dai - Small, 2024 - Wiley Online Library
Mesenchymal stem cells (MSCs) are becoming hotspots for application in disease therapies
recently, combining with biomaterials and drug delivery system. A major advantage of MSCs …

Engineered mesenchymal stem cell exosomes loaded with miR-34c-5p selectively promote eradication of acute myeloid leukemia stem cells

J Wen, Y Chen, C Liao, X Ma, M Wang, Q Li, D Wang… - Cancer Letters, 2023 - Elsevier
Most patients with acute myeloid leukemia (AML) relapse eventually because of the inability
to effectively eliminate leukemia stem cells (LSCs), prompting the search of new therapies to …

[HTML][HTML] Key role of mesenchymal stromal cell interaction with macrophages in promoting repair of lung injury

M Jerkic, K Szaszi, JG Laffey, O Rotstein… - International Journal of …, 2023 - mdpi.com
Lung macrophages (Mφs) are essential for pulmonary innate immunity and host defense
due to their dynamic polarization and phenotype shifts. Mesenchymal stromal cells (MSCs) …

Encapsulation of nano‐bortezomib in apoptotic stem cell‐derived vesicles for the treatment of multiple myeloma

Z Cao, P Li, Y Li, M Zhang, M Hao, W Li, X Mao, L Mo… - Small, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are lipid bilayer nanovesicles released from living or apoptotic
cells that can transport DNA, RNA, protein, and lipid cargo. EVs play critical roles in cell–cell …