[HTML][HTML] Signaling of nicotinic acetylcholine receptors in mononuclear phagocytes

K Richter, V Grau - Pharmacological Research, 2023 - Elsevier
Nicotinic acetylcholine receptors are not only expressed by the nervous system and at the
neuro-muscular junction but also by mononuclear phagocytes, which belong to the innate …

AIF1: function and connection with inflammatory diseases

D De Leon-Oliva, C Garcia-Montero, O Fraile-Martinez… - Biology, 2023 - mdpi.com
Simple Summary Allograft inflammatory factor 1 (AIF1) is a calcium-binding protein that
participates in intracellular processes such as phagocytosis, membrane ruffling and F-actin …

[HTML][HTML] Shared inflammatory glial cell signature after stab wound injury, revealed by spatial, temporal, and cell-type-specific profiling of the murine cerebral cortex

C Koupourtidou, V Schwarz, H Aliee, S Frerich… - Nature …, 2024 - nature.com
Traumatic brain injury leads to a highly orchestrated immune-and glial cell response
partially responsible for long-lasting disability and the development of secondary …

Macrophage/microglia polarization for the treatment of diabetic retinopathy

Y Yao, J Li, Y Zhou, S Wang, Z Zhang… - Frontiers in …, 2023 - frontiersin.org
Macrophages/microglia are immune system defense and homeostatic cells that develop
from bone marrow progenitor cells. According to the different phenotypes and immune …

Adolescent intermittent ethanol drives modest Neuroinflammation but does not escalate drinking in male rats

JI Wooden, LE Peacoe, C Anasooya Shaji… - Cells, 2023 - mdpi.com
During adolescence, the brain is highly susceptible to alcohol-induced damage and
subsequent neuroimmune responses, effects which may enhance development of an …

Obligatory role of microglia-mobilized hippocampal CREB-BDNF signaling in the prophylactic effect of β-glucan on chronic stress-induced depression-like behaviors …

C Zhao, R Shi, X Lu, R Yang, Z Chen, B Chen… - European Journal of …, 2024 - Elsevier
Our previous studies have reported that pre-stimulation of microglia before stress stimulation
is a possible strategy to prevent depression-like phenotypes; however, the molecular …

The neurotransmitter puzzle of Alzheimer's: Dissecting mechanisms and exploring therapeutic horizons

M Sharma, P Pal, SK Gupta - Brain Research, 2024 - Elsevier
Alzheimer's Disease (AD) represents a complex interplay of neurological pathways and
molecular mechanisms, with significant impacts on patients' lives. This review synthesizes …

Microglia, Trem2, and Neurodegeneration

Q Shi, RA Gutierrez, MA Bhat - The Neuroscientist, 2024 - journals.sagepub.com
Microglia are a specialized type of neuroimmune cells that undergo morphological and
molecular changes through multiple signaling pathways in response to pathological protein …

Monoclonal antibody therapy in Alzheimer's disease

M Neațu, A Covaliu, I Ioniță, A Jugurt, EI Davidescu… - Pharmaceutics, 2023 - mdpi.com
Alzheimer's disease is a neurodegenerative condition marked by the progressive
deterioration of cognitive abilities, memory impairment, and the accumulation of abnormal …

Neural progenitor cells and the hypothalamus

EA Makrygianni, GP Chrousos - Cells, 2023 - mdpi.com
Neural progenitor cells (NPCs) are multipotent neural stem cells (NSCs) capable of self-
renewing and differentiating into neurons, astrocytes and oligodendrocytes. In the …