Pathophysiology of atherosclerosis

S Jebari-Benslaiman, U Galicia-García… - International journal of …, 2022 - mdpi.com
Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading
cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and …

Mechanistic insights into the oxidized low‐density lipoprotein‐induced atherosclerosis

C Khatana, NK Saini, S Chakrabarti… - Oxidative medicine …, 2020 - Wiley Online Library
Dyslipidaemia has a prominent role in the onset of notorious atherosclerosis, a disease of
medium to large arteries. Atherosclerosis is the prime root of cardiovascular events …

Monocyte-macrophages and T cells in atherosclerosis

I Tabas, AH Lichtman - Immunity, 2017 - cell.com
Atherosclerosis is an arterial disease process characterized by the focal subendothelial
accumulation of apolipoprotein-B-containing lipoproteins, immune and vascular wall cells …

Endothelial cell dysfunction and the pathobiology of atherosclerosis

MA Gimbrone Jr, G García-Cardeña - Circulation research, 2016 - Am Heart Assoc
Dysfunction of the endothelial lining of lesion-prone areas of the arterial vasculature is an
important contributor to the pathobiology of atherosclerotic cardiovascular disease …

Recent insights into the cellular biology of atherosclerosis

I Tabas, G García-Cardeña, GK Owens - Journal of Cell Biology, 2015 - rupress.org
Atherosclerosis occurs in the subendothelial space (intima) of medium-sized arteries at
regions of disturbed blood flow and is triggered by an interplay between endothelial …

Beneficial effects of citrus flavonoids on cardiovascular and metabolic health

AM Mahmoud, RJ Hernandez Bautista… - Oxidative medicine …, 2019 - Wiley Online Library
The prevalence of cardiovascular disease (CVD) is increasing over time. CVD is a
comorbidity in diabetes and contributes to premature death. Citrus flavonoids possess …

[HTML][HTML] The role of lipids and lipoproteins in atherosclerosis

MRF Linton, PG Yancey, SS Davies, WG Jerome… - Endotext …, 2019 - ncbi.nlm.nih.gov
Atherosclerosis is the underlying cause of heart attack and stroke. Early observations that
cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for …

From Focal Lipid Storage to Systemic Inflammation: JACC Review Topic of the Week

P Libby, GK Hansson - Journal of the American College of Cardiology, 2019 - jacc.org
Abstract Concepts of atherogenesis have evolved considerably with time. Early animal
experiments showed that a cholesterol-rich diet could induce fatty lesion formation in …

Macrophage‐mediated cholesterol handling in atherosclerosis

DA Chistiakov, YV Bobryshev… - Journal of cellular and …, 2016 - Wiley Online Library
Formation of foam cells is a hallmark at the initial stages of atherosclerosis. Monocytes
attracted by pro‐inflammatory stimuli attach to the inflamed vascular endothelium and …

Cardiovascular remodelling in coronary artery disease and heart failure

G Heusch, P Libby, B Gersh, D Yellon, M Böhm… - The Lancet, 2014 - thelancet.com
Remodelling is a response of the myocardium and vasculature to a range of potentially
noxious haemodynamic, metabolic, and inflammatory stimuli. Remodelling is initially …