Plasmid-mediated virulence in Chlamydia

BJ Turman, T Darville, CM O'Connell - Frontiers in Cellular and …, 2023 - frontiersin.org
Chlamydia trachomatis infection of ocular conjunctiva can lead to blindness, while infection
of the female genital tract can lead to chronic pelvic pain, ectopic pregnancy, and/or …

Regulation of chlamydial colonization by IFNγ delivered via distinct cells

H Winner, A Friesenhahn, Y Wang, N Stanbury… - Trends in …, 2023 - cell.com
The mouse-adapted pathogen Chlamydia muridarum (CM) induces pathology in the mouse
genital tract but fails to do so in the gastrointestinal tract. CM is cleared from both the genital …

Lactobacillus Modulates Chlamydia Infectivity and Genital Tract Pathology in vitro and in vivo

H Chen, S Min, L Wang, L Zhao, F Luo, W Lei… - Frontiers in …, 2022 - frontiersin.org
Since we previously reported that women infected with chlamydia had a significant overall
reduction in Lactobacillus in the vagina microbiota as compared to those uninfected …

Chlamydia overcomes multiple gastrointestinal barriers to achieve long-lasting colonization

G Zhong - Trends in microbiology, 2021 - cell.com
Chlamydia trachomatis (CT) is frequently detected in the human gastrointestinal (GI) tract
despite its leading role in sexually transmitted bacterial infections in the genital tract …

Chlamydia spreading from the genital tract to the gastrointestinal tract–a two-hit hypothesis

G Zhong - Trends in microbiology, 2018 - cell.com
Chlamydia trachomatis, a leading bacterial cause of sexually transmitted infection-induced
infertility, is frequently detected in the gastrointestinal tract. Chlamydia muridarum, a model …

Robust Heat Shock Response in Chlamydia Lacking a Typical Heat Shock Sigma Factor

Y Huang, W Wurihan, B Lu, Y Zou, Y Wang… - Frontiers in …, 2022 - frontiersin.org
Cells reprogram their transcriptome in response to stress, such as heat shock. In free-living
bacteria, the transcriptomic reprogramming is mediated by increased DNA-binding activity of …

Preclinical screen for protection efficacy of chlamydial antigens that are immunogenic in humans

C Lu, J Wang, G Zhong - Infection and immunity, 2023 - Am Soc Microbiol
To search for subunit vaccine candidates, immunogenic chlamydial antigens identified in
humans were evaluated for protection against both infection and pathology in a mouse …

[HTML][HTML] Pgp3 protein of Chlamydia trachomatis inhibits apoptosis via HO-1 upregulation mediated by PI3K/Akt activation

M Shu, J Bu, W Lei, L Chen, Z Zhou, C Lu, C Chen… - Microbial …, 2023 - Elsevier
As an obligate intracellular pathogen, Chlamydia trachomatis assumes various strategies to
inhibit host cells apoptosis, thereby providing a suitable intracellular environment to ensure …

The Plasmid-Encoded pGP3 Promotes Chlamydia Evasion of Acidic Barriers in Both Stomach and Vagina

T Zhang, Z Huo, J Ma, C He, G Zhong - Infection and immunity, 2019 - Am Soc Microbiol
Although Chlamydia trachomatis is a human genital tract pathogen, chlamydial organisms
have frequently been detected in both vaginal and rectal swab samples of animals and …

Bringing genetics to heretofore intractable obligate intracellular bacterial pathogens: Chlamydia and beyond

M Ölander, BS Sixt - PLoS Pathogens, 2022 - journals.plos.org
As their designation implies, obligate intracellular bacteria are microbes that have
developed lifestyles so closely entwined with the cells of the hosts they infect that they can …