Abnormal wound healing is a major complication of both type 1 and type 2 diabetes, with
nonhealing foot ulcerations leading in the worst cases to lower-limb amputation. Wound …

The origins of the major classes of current anti-emetics are examined. Serendipity is a
recurrent theme in discovery of their anti-emetic properties and repurposing from one …

Extensive efforts since 1931, on the structural determination of the mammalian tachykinin SP
by NMR, CD and IR have turned out to be inconclusive. Studies are now being concentrated …

The tachykinins substance P and neurokinin A are present in human airways, in sensory
nerves and immune cells. Tachykinins can be recovered from the airways after inhalation of …

Although current antipsychotic drugs are effective at treating the psychotic (positive)
symptoms of schizophrenia, they have one or more serious side effects, including …

Tachykinins (substance P, neurokinin A, and neurokinin B) are pro-inflammatory
neuropeptides that may play an important role in some autoimmune neuroinflammatory …

Selective, nonpeptide antagonists for tachykinin receptors first became available ten years
ago. Of the three known tachykinin receptors, drug development has focused most …

NK1 and NK3 receptors do not appear to play significant roles in normal GI functions, but
both may be involved in defensive or pathological processes. NK1 receptor antagonists are …

The tachykinin family has recently been extended by the discovery of a third tachykinin gene
encoding previously unknown mammalian tachykinins (hemokinin 1, endokinin A and …

In vertebrates, the tachykinin system includes tachykinin genes, which encode one or two
peptides each, and tachykinin receptors. The complexity of this system is reinforced by the …