This review is focused on purinergic neurotransmission, ie, ATP released from nerves as a
transmitter or cotransmitter to act as an extracellular signaling molecule on both pre-and …

Adenosine acts in parallel as a neuromodulator and as a homeostatic modulator in the
central nervous system. Its neuromodulatory role relies on a balanced activation of inhibitory …

Abstract Dopamine D2 receptors (D2Rs) are densely expressed in the striatum and have
been linked to neuropsychiatric disorders such as schizophrenia,. High-affinity binding of …

There are numerous problems with the hypothesis that brain dopamine (DA) systems,
particularly in the nucleus accumbens, directly mediate the rewarding or primary …

The existence of G protein-coupled receptor (GPCR) dimers and/or oligomers has been
demonstrated in heterologous systems using a variety of biochemical and biophysical …

The dawn of chemical neuroanatomy in the CNS came with the discovery and mapping of
the central dopamine, noradrenaline and 5-hydroxytryptamine neurons by means of …

G protein‐coupled receptors are known to form homo‐and heteromers at the plasma
membrane, but the stoichiometry of these receptor oligomers are relatively unknown. Here …

G protein-coupled receptors (GPCRs) are cell surface receptors that mediate physiological
responses to a diverse array of stimuli. GPCRs have traditionally been thought to act as …

Mesolimbic dopamine (DA) is involved in behavioral activation and effort-related processes.
Rats with impaired DA transmission reallocate their instrumental behavior away from food …

Adenosine A2A receptor (A2AR)-dopamine D2 receptor (D2R) heteromers are key
modulators of striatal neuronal function. It has been suggested that the psychostimulant …