Atherosclerosis is one type of cardiovascular disease (CVD) in which activation of the
NLRP3 inflammasome and toll-like receptor (TLR) pathways is implicated. One of the most …

Atherosclerosis is a chronic disease of the arterial wall where both innate and adaptive
immunoinflammatory mechanisms are involved. Inflammation is central at all stages of …

For many years, the interleukin-1 receptor family member ST2 was an orphan receptor that
was studied in the context of inflammatory and autoimmune disease. However, in 2005, a …

Toll-like receptors (TLRs) play an important part in the innate immune recognition of
invading microorganisms, initiating sufficient immune responses. Growing amounts of data …

Extensive evidence implicates inflammation in multiple phases of stroke etiology and
pathology. In particular, there is growing awareness that inflammatory events outside the …

The Toll-like receptor 4 (TLR4) signaling pathway plays a central role in the prompt defense
against infectious challenge and provides immediate response to Gram-negative bacterial …

Toll-like receptors (TLRs) are a group of pattern recognition molecules that play a crucial
role in innate immunity. The structural conservation of the archaic TLR system suggests that …

Although in developing countries an apolipoprotein E4 (apoE4) genotype may offer an
evolutionary advantage, as it has been shown to offer protection against certain infectious …

Lipid droplets (LDs) are neutral lipid storage organelles ubiquitous to eukaryotic cells. It is
increasingly recognized that LDs interact extensively with other organelles and that they …

Background—Myeloid-related protein (MRP)-8 (S100A8) and MRP-14 (S100A9) are
members of the S100 family of calcium-modulated proteins that regulate myeloid cell …