[HTML][HTML] A review of environmental metabolism disrupting chemicals and effect biomarkers associating disease risks: Where exposomics meets metabolomics
J Sun, R Fang, H Wang, DX Xu, J Yang, X Huang… - Environment …, 2022 - Elsevier
Humans are exposed to an ever-increasing number of environmental toxicants, some of
which have gradually been elucidated to be important risk factors for metabolic diseases …
which have gradually been elucidated to be important risk factors for metabolic diseases …
Toxicity testing in the 21st century: progress in the past decade and future perspectives
D Krewski, ME Andersen, MG Tyshenko… - Archives of …, 2020 - Springer
Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …
based on expanded application of high-throughput in vitro screening and in silico methods …
[HTML][HTML] The toxicity of nanoparticles and their interaction with cells: an in vitro metabolomic perspective
Nowadays, nanomaterials (NMs) are widely present in daily life due to their significant
benefits, as demonstrated by their application in many fields such as biomedicine …
benefits, as demonstrated by their application in many fields such as biomedicine …
Systems toxicology: from basic research to risk assessment
Systems Toxicology is the integration of classical toxicology with quantitative analysis of
large networks of molecular and functional changes occurring across multiple levels of …
large networks of molecular and functional changes occurring across multiple levels of …
[HTML][HTML] “Omics”-informed drug and biomarker discovery: opportunities, challenges and future perspectives
H Matthews, J Hanison, N Nirmalan - Proteomes, 2016 - mdpi.com
The pharmaceutical industry faces unsustainable program failure despite significant
increases in investment. Dwindling discovery pipelines, rapidly expanding R&D budgets …
increases in investment. Dwindling discovery pipelines, rapidly expanding R&D budgets …
Promises and challenges of big data computing in health sciences
With the development of smart devices and cloud computing, more and more public health
data can be collected from various sources and can be analyzed in an unprecedented way …
data can be collected from various sources and can be analyzed in an unprecedented way …
[HTML][HTML] t4 workshop report: State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology
N Alépée, A Bahinski, M Daneshian, B De Wever… - Altex, 2014 - ncbi.nlm.nih.gov
Integrated approaches using different in vitro methods in combination with bioinformatics
can (i) increase the success rate and speed of drug development;(ii) improve the accuracy of …
can (i) increase the success rate and speed of drug development;(ii) improve the accuracy of …
[HTML][HTML] Use cases, best practice and reporting standards for metabolomics in regulatory toxicology
MR Viant, TMD Ebbels, RD Beger, DR Ekman… - Nature …, 2019 - nature.com
Metabolomics is a widely used technology in academic research, yet its application to
regulatory science has been limited. The most commonly cited barrier to its translation is …
regulatory science has been limited. The most commonly cited barrier to its translation is …
[HTML][HTML] Simultaneously discovering the fate and biochemical effects of pharmaceuticals through untargeted metabolomics
Untargeted metabolomics is an established approach in toxicology for characterising
endogenous metabolic responses to xenobiotic exposure. Detecting the xenobiotic and its …
endogenous metabolic responses to xenobiotic exposure. Detecting the xenobiotic and its …
[HTML][HTML] Prediction of liver toxicity and mode of action using metabolomics in vitro in HepG2 cells
T Ramirez, A Strigun, A Verlohner, HA Huener… - Archives of …, 2018 - Springer
Liver toxicity is a leading systemic toxicity of drugs and chemicals demanding more human-
relevant, high throughput, cost effective in vitro solutions. In addition to contributing to animal …
relevant, high throughput, cost effective in vitro solutions. In addition to contributing to animal …